Biochem

Question 0

Makes DNA active

Answer 0

Acetylation

Question 1

Makes DNA mute

Answer 1

Methylation

Question 2

Purines

Answer 2

A, G - 2 rings

“PURAG”
“PURe As Gold”

Question 3

Pyimidines

Answer 3

C,U,T - 1 ring

“CUT the PY”
PyriCUT

Question 4

Deamination of cytosine makes?

Answer 4

Uracil

Question 5

Thyimine has?

Answer 5

Methyl

Question 6

Between Thymine and Uracil,which is found in DNA and which is found in RNA?

Answer 6

Uracil in RNA “uRacil in RNA”

thymine in DNA

Question 7

Amino acids necessary for purine synthesis

Answer 7

Glycine
Aspartate
Glutamine

GAG

Question 8

Which is a stronger bond and thus has a higher melting temperature between CG and AT?

Answer 8

CG has 3 H bonds and is thus stronger

AT has only 2 H bonds

Question 9

Only histone that is not in the nucleosome core?

Answer 9

H1

Question 10

Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Inhibits ribonucleotide reductase.

Answer 10

Hydroxyurea

Question 11

Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Blocks de novo purine synthesis.

Answer 11

6-Mercaptopurine

Question 12

Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Inhibits thymidilate synthase

Answer 12

5-fluorouracil

Question 13

Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Ihibits dihydrofolate reductase

Answer 13

Methotrexate

Question 14

Antineoplastic/antibacterial drug which interferes with nucleotide synthesis. Inhibits bacterial dihydrofolate reductase

Answer 14

Trimethoprim

Question 15

Purine salvage deficiency. Absence of HGPRT which converts hypoxanthine to IMP and Guanine to GMP.

Answer 15

Lesch-Nyhan Syndrome

Question 16

Purine salvage deficiency. Results in escess uric acid production and de novo purine synthesis

Answer 16

Lesch-Nyhan syndrome

Question 17

Mutation in DNA. Same aa, base change in 3rd position of codon (tRNA wobble)

Answer 17

Silent Mutation

Question 18

Mutation in DNA. CHANGED aa

Answer 18

Missense mutation

Question 19

Mutation in DNA. Change resulting in early stop codon

Answer 19

Nonsense mutation

“stop the nonsense!”

Question 20

Mutation in DNA. Change resulting in misreading of all nucleotides downstream, usually resulting in a truncated, non functional protein

Answer 20

Frameshift mutation