Path: WBC, Spleen, Thymus

Question 1

EBV infection

Answer 1

Infects B-cells, but causes T-cell proliferation with follicular effacement

Question 2

t(12;21), CD10/19/20 in a child, GOOD prognosis

Answer 2

B-ALL

Question 3

t(9;22), CD10/19/20 in an adult, POOR prognosis

Answer 3

B-ALL

Question 4

PAS+, MPO-, TdT-

Answer 4

B or T-ALL

Question 5

CD19/20/23 + CD5

Clock Face Chromatin, smudge cells, splenomegaly, general LAD

Answer 5

CLL/SLL

Question 6

TRAP, BRAF, CD19/20, CD11c, incr. infection with Atypical Mycobacterium

Answer 6

Hairy Cell Leukemia

Question 7

t(14;18) –> BCL2

CD19/20/10/BCL6, CD5-

Answer 7

Follicular Lymphoma

Question 8

t(11;14) –> Cyclin D

CD5+, Painless LAD

Answer 8

Mantle Cell Lymphoma

Question 9

t(11;18) or t(1;14) –> BCL10, MALT1

Answer 9

Marginal Zone Lymphoma

Question 10

t(8;14)/t(2;8)/t(8;22) –> c-MYC

Answer 10

Burkitt Lymphoma

Question 11

Starry-Sky Pattern (tingle-body macrophages)

Answer 11

Burkitt Lymphoma

Question 12

What type of cells have CD10/BCL6

Answer 12

Germinal Center B-Cells

Question 13

B cell neoplasm assoc. w/ GI masses & jaw abscess

Answer 13

Burkitt Lymphoma

Question 14

Associated w/ EBV and KSHV/HHV-8

CD10/BCL6 cells

Answer 14

DLBCL

Question 15

CD4+ T-Cells
Assoc: HTLV-1 infection; Progressive Demyelinating Disease of the CNS
Cloverleaf/Flower cells (multilobated nuclei)

Answer 15

Adult T-Cell Leukemia/Lymphoma

Question 16

Cerebriform T-Cells and Eosinophils

CLA+, cause Exfoliative Erythroderma

Answer 16

Mycosis Fungoides/Sezary Syndrome

Question 17

STAT3, abundant blue cytoplasm

Assoc: Felty Syndrome (RA, Splenomegaly, Neutropenia)

Answer 17

Large Granular Lymphocytic Leukemia

Question 18

CD2/3/5+ Lymphoma

Eosinophils, Macrophages, Angiogenesis, LN effacement

Answer 18

Peripheral T-Cell Lymphoma, unspecified

Question 19

CD30, ALK+

large Hallmark T-Cells (horseshoe nucleus, voluminous cytoplasm), vascular clustering

Answer 19

Anaplastic Large-Cell Lymphoma

Question 20

Aggressive Lymphoma w/ only NK-cell markers (CD56)

Azurophilic granules, pyknotic nuclei, ischemic necrosis

Answer 20

Extranodal NK/T-Cell Lymphoma

Question 21

CD15/CD30/PAX5 Lymphoma

Answer 21

Classical Hodgkin Lymphoma

Question 22

CD20/BCL6 Lymphoma

Answer 22

Non-Classical Lymphoma

Question 23

Most common Infection with Hodgkin Lymphoma

Answer 23

EBV

Question 24

CD138, Syndecan-1, Russel Bodies, Dutcher Bodies

IgG M-protein spike, lytic lesions (hypercalcemia), kappa light chains (Bence-Jones proteins), Rouleaux formation, ,

Answer 24

Multiple Myeloma

Question 25

MYD88, PAS+, CD20, Russel Bodies, Dutcher Bodies

IgM hyperviscosity, splenomegaly, NO bone destruction or renal failure

Answer 25

Lymphoplasmacytic Lymphoma (Waldenstrum Macroglobulinemia)

Question 26

t(15;17)/M3/WHO 1, MPO+, Auer Rods

Answer 26

Acute Promyelocytic Leukemia (APL) = granulocytosis w/ left shift

Question 27

inv(16)/M4/WHO 1, Esterase+, Leukemia Cutis, mucosal hemorrhages

Answer 27

Acute Monocytic Myelogenous Leukemia (AMML) = monocytosis

Question 28

t(8;21)/M2/WHO 1

Answer 28

AML

Question 29

Monosomy 5,7; Deletion 5q,7q,20q; Trisomy 8

Answer 29

Myelodysplastic Syndromes

Question 30

RBC: Ring Sideroblasts
Neutrophils: Bi-lobate, Dohle Bodies, Pseudo-pegler-huet cells
Megakaryocytes: large, pawn ball megakaryocytes
Giant platelets

Answer 30

Myelodysplastic Syndrome

Question 31

t(9;22) –> BCR-ABL

Answer 31

CML or adult B-ALL

Question 32

JAK2 w/ increased RBC, Granulocytes, Platelets (Panmyelosis), low EPO

Answer 32

Polycythemia Vera (myeloproliferative)

Question 33

JAK2, MPL, Reticulin w/ increased platelets only

Answer 33

Essential Thrombocytosis (Myeloproliferative)

Question 34

JAK2, MPL, Reticulin w/ BM fibrosis, Leukoerythroblastosis (tear-drop cells)

Answer 34

Primary Myelofibrosis

Question 35

Birbeck Granules, BRAF, HLA-DR, S-100, CD1a

Answer 35

Langerhans Cell Histiocytosis