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COM - Heme/Lymph > Path: RBC, Bleeding Disorders > Flashcards

Path: RBC, Bleeding Disorders Flashcards

1
Q

Low ferritin/High TIBC/Low Hepcidin; Low serum Fe/Low % saturation; High RDW/High FEP; Low Hct/Low Hb

A

Iron-Deficiency Anemia (IDA)

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2
Q

Associated Illness with IDA

A

Plummer-Vinson Syndrom (Anemia, Esophageal Webs, Dysphagia)

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3
Q

Increased IL-6 APP –> Increased Hepcidin –> decreased Ferroportin and EPO

A

Anemia of Chronic Disease

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4
Q

High ferritin/low TIBC; low serum Fe/Low % saturation; High FEP; low EPO

A

Anemia of Chronic Dz

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5
Q

Deletion in Chr. 16

A

Alpha Thalassemia

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6
Q

Mutation in Chr. 11

A

Beta Thalassemia

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7
Q

Hb Barts

A

Gamma tetramers, 4 gene deletion in Alpha Thalassemia

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8
Q

HbH

A

Beta tetramers, 3 gene deletion in Alpha Thalassemia

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9
Q

HbF > HbA2

A

B-Thal Major

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10
Q

HbA2 > HbF

A

B-Thal Minor

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11
Q

Low RBC, hypersegmented Neutrophils, MCV >100

A

Megaloblastic Anemia

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12
Q

Incr. Homocysteine, Normal Methymalonic Acid, MCV >100

A

Folate Deficiency

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13
Q

Incr. Homocysteine, Incr. Methylmalonic Acid, MCV >100

A

B12 Deficiency

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14
Q

AI Atrophic Gastritis –> AI T-cells

A

Pernicious Anemia –> B12 deficiency

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15
Q

Ankyrin, Spectrin, Band3, Howell-Jolly Bodies

A

Hereditary Spherocytosis (Extravascular)

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16
Q

HbS

A

Valine substitution –> Sickle-Cell Anemia

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17
Q

HbSC

A

Valine & Lysine substitutions –> mild sickling

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18
Q

PIGA –> GPI proteins (MIRL, DAF, C8 binding protein)

A

Paroxysmal Nocturnal Hemoglobinuria (PNH) = intravascular hemolysis

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19
Q

Heinz Bodies, Bite Cells; X-linked recessive; intermittent hemolysis

A

G6PD Deficiency

20
Q

Warm Agglutinins

A

IgG

21
Q

Cold Agglutinins

A

IgM

22
Q

D-dimers, Schistocytes

A

Microangiopathic Hemolytic Anemia

23
Q

Fanconi Anemia

A

Aplastic Anemia

24
Q

Parvovirus B19

A

Pure Red Cell Aplasia (decreases RBCs)

25
Q

Space occupying lesion –> suppressed BM –> Tear-drop RBC and Leukoerythroblastosis (immature granulocytes and RBC)

A

Myelophthistic Anemia

26
Q

Uremia + Extracorpuscular defects + Decreased EPO synthesis –> underproduce RBCs

A

Chronic Renal Failure

27
Q

Gaisbock Syndrome

A

Stress Polycythemia = reduced plasma volume with HTN, obese, anxious patient

28
Q

Stabilized HIF1-alpha –> increased EPO

A

Secondary Polycythemia

29
Q

PTT, Heparin pathway (less important)

A

Intrinsic

30
Q

PT, Tissue damage, Coumadin pathway (most important)

A

Extrinsic

31
Q

Purpuric rash, colic, polyarthralgia, acute glomerulonephritis

A

Henoch-Schonlein Purpura

32
Q

TGF-B; tortuous veins, epistaxis and other very serious bleeding complications

A

Weber-Osler-Rendu Syndrome

33
Q

Peripheral Megathrombocytes, Increased BM megakaryocytes, large peripheral platelets, no splenomegaly or LAD; petechial hemorrhages

A

Chronic Immune Thrombocytopenic Purpura (hemorrhage)

34
Q

Follicular B-cell hyperplasia –> Auto-Abs to GPIIb/IIIa

A

HIV-associated Thrombocytopenia

35
Q

ADAMTS13 –> excessive platelet activation

A

Thrombotic Thrombocytopenic Purpura (thromboses)

36
Q

E.Coli activated thrombotic microangiopathy

A

Hemolytic Uremic Syndrome (HUS)

37
Q

GPIb-Ix (Aut. Rec.) –> Platelet Adhesion defect

A

Bernard-Soulier Syndrome

38
Q

GPIIb/IIIA (Aut. Rec.) –> Platelet Aggregation defect

A

Glanzmann Thrombasthenia

39
Q

Prolonged PTT

A

vWF, Hemophilia A/B

40
Q

ADAMTS13 + normal platelets, prolonged PTT, hemarthoris

A

vWF (Type 3) = Aut. Recessive

41
Q

Factor VIII deficiency; hemarthorses; prolonged PTT

A

Hemophilia A (X-linked Recessive)

42
Q

Factor IX deficiency; hemarthroses; prolonged PTT

A

Hemophilia B (X-linked recessive)

43
Q

Non-immunologic Thrombocytopenia, MAJOR bleeding, triggered by Tissue Factor; hemorrhage and thromboses

A

DIC

44
Q

IgG reaction to IgA in donor blood

A

IgA deficiency

45
Q

Acute Transfusion hemolysis

A

IgG

46
Q

Delayed Transfusion hemolysis

A

IgM

47
Q

Acute Respiratory Depression, Hypotension, hypoxemia, increased activated neutrophils AFTER transfusion

A

TRALI

COM - Heme/Lymph (4 decks)

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