Path pics 2 Flashcards
esophageal varices
esophageal varices
varices
Stomach
Portal Hypertensive Gastropathy
Stomach
Portal Hypertensive Gastropathy
This person have ALD and?
Stain?
Hemochromatosis
lots of scarring
prussian blue stain: iron
ALD patient that also has?
Stain?
alpha-1 antitrypsin deficiency
PAS
Possible reason for these?
Mallory-Denk bodies
tangled intermediate filaments with other proteins
seen in: ALD
What types of hepatitis do you NOT see this in?
alcohoic liver disease
steatosis: macrovesicular steatosis associated with hepatocyte ballooning
not seen in: viral or autoimmune hepatitis
Earliest sign of hepatic fibrosis in this disease?
ALD
alcholic cirrhosis
earliest sign of hepatic fibrosis in ALD: perivenular fibrosis
Most common cause?
other causes?
left: micronodular cirrhosis (small regenerative nodules)
right: micronodular cirrhosis with macrovesicular steatosis (regenerative nodule surrounded by fibrous CT btwn portal regions)
most common cause: chronic alcoholism
other: Wilson’s, primary biliary cirrhosis, hemochromatosis
ALD
left: cirrhosis
right: cirrhosis that is reversing
Liver
US of Fatty liver
increase echogenicity throughout
Fatty liver
MRI/CT: enlarged liver that is a different density of spleen
NAFLD
left: macrovesicular steatosis, Mallory, hepatocyte ballooning
right: perivenular and perisinusoidal fibrosis (CHICKEN WIRE)
left: hemochromatosis
right: iron overload due to transfusions
left: normal
right: hemochromatosis
Kayser-Fleischer ring
Wilson’s
Alpha-1 anti-trypsin
cerebral edema from acute hepatitis
left: normal
right: cirrhotic hepatocerebral degeneration
Globus Pallidus with myelin degeneration
Alzhemier type II Astrocytes
encephalopathy
Alzheimer’s type II astrocytes
encephalopathy
cryoglobulinemia
precipitated proteins in chilled blood
membranoproliferative glomerulonephritis
What drug?
fatty liver
carbon tetrachloride
What drug caused this liver disease?
Bland cholestasis
oral contraceptives
Angiosarcoma
polyvinyl chloride
What drug?
angiosarcoma
POLYVINYL CHLORIDE
liver failure (drug induced)
zonal necrosis around 3 central veins while hepatocytes near portal areas remain viable
Drug induced liver disease
Hepatitis, neutrophilic, lymphocytic, eosinophilic, granulomatous or any combination
Drug induced liver disease
Hepatocyte hydropic (ballooning) degeneration
What drug?
cholestasis
chlorpormazine
drug induced liver disease
canalicular cholestasis: bile plugs
Drug?
phospholipidosis
amiodarone
Acute liver failure
metastatic small cell lung carcinoma
Smoker in acute liver failure
liver with metastasis
small cell lung carcinoma
