Path pics 2

Question 1

Answer 1

esophageal varices

Question 2

Answer 2

esophageal varices

Question 3

Answer 3

varices

Question 4

Stomach

Answer 4

Portal Hypertensive Gastropathy

Question 5

Stomach

Answer 5

Portal Hypertensive Gastropathy

Question 6

This person have ALD and?

Stain?

Answer 6

Hemochromatosis

lots of scarring

prussian blue stain: iron

Question 7

ALD patient that also has?

Stain?

Answer 7

alpha-1 antitrypsin deficiency

PAS

Question 8

Possible reason for these?

Answer 8

Mallory-Denk bodies

tangled intermediate filaments with other proteins

seen in: ALD

Question 9

What types of hepatitis do you NOT see this in?

Answer 9

alcohoic liver disease

steatosis: macrovesicular steatosis associated with hepatocyte ballooning

not seen in: viral or autoimmune hepatitis

Question 10

Earliest sign of hepatic fibrosis in this disease?

Answer 10

ALD

alcholic cirrhosis

earliest sign of hepatic fibrosis in ALD: perivenular fibrosis

Question 11

Most common cause?

other causes?

Answer 11

left: micronodular cirrhosis (small regenerative nodules)
right: micronodular cirrhosis with macrovesicular steatosis (regenerative nodule surrounded by fibrous CT btwn portal regions)

most common cause: chronic alcoholism

other: Wilson’s, primary biliary cirrhosis, hemochromatosis

Question 12

Answer 12

ALD

left: cirrhosis
right: cirrhosis that is reversing

Question 13

Liver

Answer 13

US of Fatty liver

increase echogenicity throughout

Question 14

Answer 14

Fatty liver

MRI/CT: enlarged liver that is a different density of spleen

Question 15

Answer 15

NAFLD

left: macrovesicular steatosis, Mallory, hepatocyte ballooning
right: perivenular and perisinusoidal fibrosis (CHICKEN WIRE)

Question 16

Answer 16

left: hemochromatosis
right: iron overload due to transfusions

Question 17

Answer 17

left: normal
right: hemochromatosis

Question 18

Answer 18

Kayser-Fleischer ring

Wilson’s

Question 19

Answer 19

Alpha-1 anti-trypsin

Question 20

Answer 20

cerebral edema from acute hepatitis

Question 21

Answer 21

left: normal
right: cirrhotic hepatocerebral degeneration

Question 22

Answer 22

Globus Pallidus with myelin degeneration

Question 23

Answer 23

Alzhemier type II Astrocytes

encephalopathy

Question 24

Answer 24

Alzheimer’s type II astrocytes

encephalopathy

Question 25

Answer 25

cryoglobulinemia

precipitated proteins in chilled blood

Question 26

Answer 26

membranoproliferative glomerulonephritis

Question 27

What drug?

Answer 27

fatty liver

carbon tetrachloride

Question 28

What drug caused this liver disease?

Answer 28

Bland cholestasis

oral contraceptives

Question 29

Answer 29

Angiosarcoma

polyvinyl chloride

Question 30

What drug?

Answer 30

angiosarcoma

POLYVINYL CHLORIDE

Question 31

Answer 31

liver failure (drug induced)

zonal necrosis around 3 central veins while hepatocytes near portal areas remain viable

Question 32

Answer 32

Drug induced liver disease

Hepatitis, neutrophilic, lymphocytic, eosinophilic, granulomatous or any combination

Question 33

Answer 33

Drug induced liver disease

Hepatocyte hydropic (ballooning) degeneration

Question 34

What drug?

Answer 34

cholestasis

chlorpormazine

Question 35

Answer 35

drug induced liver disease

canalicular cholestasis: bile plugs

Question 36

Drug?

Answer 36

phospholipidosis

amiodarone

Question 37

Acute liver failure

Answer 37

metastatic small cell lung carcinoma

Question 38

Smoker in acute liver failure

Answer 38

liver with metastasis

small cell lung carcinoma