Path lab slides Flashcards
Benign Prostatic Hyperplasia
Ceseating necrotizing granuloma (Mycobacterial TB)
Coagulative necrosis in cardiac muscle
Forgein body granuloma
Forgein body granuloma
Hypertrophic scar type 3 collagen deposition in dermis parallel to epidermis
describe
Hypertrophic scar type 3 collagen deposition in dermis parallel to epidermis
describe
Hypertrophic scar type 3 collagen deposition in dermis parallel to epidermis
Hypertrophied cardiac myocytes + enlarged nuclei
describe
Keloid Disorganized type 1 collagen deposition in dermis
Keloids
Liquefactive necrosis (brain)
Liquefactive necrosis (brain)
Meningioma (Psammoma bodies)
Meningioma CT
Metastatic calcification (ground glass opacities)
Normal myocardium
Diagnosis/Abnormality: Hypertrophic Scar (Parallel Type III collagen fibers); the healing from the scar regresses to within the boundaries, laceration on hand/arm.
Type III collagen deposition in dermis parallel to epidermis.
Old man who went gardening bare-foot. Some glass pieces went into his foot, but he has no pain. He says this happened quite a while ago. He came to you because he said it was infected and inflamed. You take the biopsy. Could be a diabetic ulcer, you cut it out – it doesn’t heal all the way properly.
Foreign Body Granuloma
Description
Giant cells have central nuclei; foreign bodies are seen in crystalline deposits surrounded by epithelioid macrophages. Langerhans giant cells
Description
Mass growing on ear after injury to the site. Biopsy reveals non-parallel/disorganized type I collagen fibers.
Double Vision (Diplopia) and headache. MRI will show a ball in the occipital lobe. Blood calcium levels are normal (no affect on calcium)
Meningioma
Psammoma bodies causes necrosis and deposits calcium inside the brain
Meningioma
Only tumor that causes dystrophic calcification
Meningioma
Patient has known renal failure, diabetic, chest pain, SOB, creatinine is high (indicates kidney poor kidney function) Shows ground glass opacities.
Metastatic calcifications
Chronic Renal Failure Acts on bone and other tissue to release their calcium into the blood, which builds up in different organs. Abnormal bone metabolism high phosphorus and calcium
Metastatic calcification
Glands are hyperplastic, papillary-like infoldings with myoepithelial cell layer (small nuclei near BM) What divides the glands from each other? The stroma (purple colour line) There is a double layer of columnar cells (there is normally a single layer) (the cells look normal, but there are just more in number)
Old man comes to you dribbling urine
BPH
Caseous Necrosis (Cream cheese-y) granuloma; Mycobacterial Tuberculosis
Peripheral rim of epithelioid histocytes (Arrows); Caseous material (asterisk) Multinucleated giant cells (triangles) All the way to the left, is the outer rim of lymphocytes and plasma cells. Caseous granuloma Giant cells nuclei are always peripheral; foreign body granuloma J cells nuclei are central.
Caseous necrosis
Homeless alcoholic comes to you, he has a cavity in his lung, aspiration of food.
Caseous necrosis
Liquefactive necrosis; Stroke/Ischemic Stroke/Ischemic Infarction
Cell Morphology: Pale areas showing pale infraction, otherwise would be red for haemorrhagic infarction. Loss of neurons and neuroglial cells, clear space seen.
Patient comes in with stroke like symptoms, contralateral lesion to where the injury is. CT scan will reveal that the patient had a stroke. Biopsy will be taken and shows the images above. Focal loss of blood supply to the portion of cerebrum.
Liquefactive necrosis
Coagulative Necrosis; Neutrophils are seen where the nuclei is supposed to be. Could be secondary to Myocardial infarction
Cardiac tissue with normal cardiac muscle architecture. Indicated parts of the tissue are missing nuclei.
Coagulative necrosis
Daughter comes to Mother from New Jersey, chest pain she is taking tums for gas, she goes in to management at hospital, she dies. Biopsy is taken but how do we determine when she had the Myocardial Infarction?
2 Weeks ~fibrous tissue
2-3 Days ~ macrophages
2 Days ~ neutrophils (minimum 24hrs)
4-5 Hrs ~ chest pain
Hypertrophy, secondary to hypertension.
Describe
Cardiac Tissue, ENLARGED Cardiac Myocytes, compared to the normal slide, the cells are enlarged and the nuclei themselves within the cells (myocytes) are enlarged
Chest pain, SOB, HTN, and diabetes. Pedal edema. Auscultation shows crackles. X-ray shows pulmonary edema. EKG shows ST elevation. Management in hospital continued Patient has died. Biopsy of the Patient shows the slide above.
Hypertrophy, secondary to hypertension.
Normal cardiac tissue
