Chronic Inflammation Flashcards
Dominant cells mediating chronic inflammation are?
Macrophages
Classical activation of a macrophage:
Inflammatory pathway
INF-y activates macrophages to release:
- ROS, NO, Lysosomal enzymes (Phagocytosis)
IL-1, IL-12, IL-23, chemokines (Inflammation)
IL-13 & IL-4 Inhibits
Alternative activation of a macrophage:
Wound repair pathway
IL-13 & IL-4 activate macrophages to release:
- Growth factors & TGF-B (Tissue repair + fibrosis)
- IL-10 & TGF-B (Anti-inflammatory)
INF-y inhibits
After_____ hrs become the dominant cell type in extra vascular tissue during inflammation
Macrophages
Role of T-cells in chronic inflammation
- Active macrophages secrete _______to recruit leukocytes
- Active macrophages secrete IL-1 & TNF to recruit leukocytes
Role of T-cells in chronic inflammation
Active macrophages secrete ______ to recruit T-lymphocytes (mainly CD4+Tcells)
Cytokines IL-1, IL-12, IL-23
Role of T-cells in chronic inflammation
TH1 cells produce _____ to activate macrophages via the classical pathway
INF-y
Role of T-cells in chronic inflammation
Activated CD4+ cells are subdivided into _____ & ______ cells
TH1 & TH17
Role of T-cells in chronic inflammation
TH17 cells secrete _____ which is responsible for recruiting neutrophils
IL-17
_____ Recruits eosinophils
Eotaxin
Eosinophils are predominant in ______ reactions & _____ mediated reactions
parasitic & IgE mediated reactions
Eosinophils kill parasites via ___________
Major basic protein
Ancyclostoma duodenale. A parasitic worm infection in the colon look for cecal mucosal with chronic inflammation and lots of eosinophils
Granulomatous inflammation is described as
Chronic inflammation & a granuloma (aggregation of macrophages, fibroblasts, lymphocytes, Giant cells, & epithelioid cells)
can be caseating or non-caseating
Giant Langhans cells
Forgien body granuloma
