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Reproductive > PATH: Endometrium and Myometrium > Flashcards

PATH: Endometrium and Myometrium Flashcards

1
Q

What is a common pathological finding of endometrial hyperplasia?

A

high gland: stromal ratio

very little space between intervening stroma

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2
Q

What is a rough way to tell if you are looking at non-atypical versus atypical hyperplasia?

A

the cells of atypical will be much darker

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3
Q

If you see really abnormal endometrium with a central area of necrosis (PMNs), what should you automatically expect?

A

endometrial carcinoma

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4
Q

Who gets type I endometrial carcinoma?

A

55-65 yo

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5
Q

Who gets type II endometrial carcinoma?

A

65-75 yo

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6
Q

What is the setting of type I endometrial carcinoma?

A

unopposed estrogen
obesity
HTN
diabetes

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7
Q

What is the setting of type II endometrial carcinoma?

A

atrophy

thin physique

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8
Q

What is the morphology of type I endometrial carcinoma?

A

endometriod

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9
Q

What is the morphology of type II endometrial carcinoma?

A

serous or mixed mullerian tumor

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10
Q

What is the precursor to type I endometrial carcinoma?

A

hyperplasia

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11
Q

What is the precursor to type II endometrial carcinoma?

A

serous endometrial intraepithelial carcinoma

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12
Q

List the mutations in order for type I endometrial carcinoma.

A

Normal–> PTEN mutation and MLH1 mutation
Non-atypical hyperplasia–> KRAS, macrosatellite instability
Atypical hyperplasia –> ARID1A, PIK3CA, CTNNB1, FGFR2
Grade 1 uterine endometrioid carcinoma

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13
Q

List the mutations in order for type II endometrial carcinoma.

A

Atropic endometrium–> TP53 aneuploidy

Serous endometrial intraepithelial carcinoma–> FBXW7, PPP2R1A, CCNE1

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14
Q

What is the behavior of type I endometrial carcinoma?

A

indolent

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15
Q

How does type I endometrial carcinoma spread?

A

lymphatics

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16
Q

What is the behavior of type II endometrial carcinoma?

A

aggressive

17
Q

How does type II endometrial carcinoma spread?

A

intraperitoneal and lymphatic spread

18
Q

What type of microscopic pattern does type II endometrial carcinoma have?

A

papillary pattern

19
Q

What do you think of if you see a circumscribed nodule in the myometrium?

A

leiomyoma

20
Q

What is the microscopic pathology of a leiomyoma?

A

smooth muscle cells elongated and have eosinophilic cytoplasm and elongated, cigar-shaped nuclei (uniform with sparse or absent mitotic figures)

Reproductive (21 decks)

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