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Passmed > PATH > Flashcards

PATH Flashcards

1
Q

Burkit histological feature

A

starry sky sign: lymphocyte sheets interspersed with macrophages containing dead apoptotic tumour cells

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2
Q

Burkit risk factors?

A

EBV

c-myc

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3
Q

How myeloma cause hyperviscosity?

A

high paraprotein levels cause hyperviscosity: high risk of stroke

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4
Q

Why high calcium level in myeloma

A

Myeloma cells release TNF/ IL1 which cause osteoclastic activity

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5
Q

Blood film for myelofibrosis

A

tear drop poikilocytes

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6
Q

Blood film for iron deficiency anaemia

A

pencil shape poikilocytes

target cells

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7
Q

Blood film for hyposplenism

A 
target cells
Howell-Jolly bodies
Pappenheimer bodies
siderotic granules
acanthocytes
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8
Q

Splenectomy pathogens susceptibility

A

pneumococcus,
Haemophilus,
meningococcus
Capnocytophaga canimorsus (dog bite)

Typically occurs with encapsulated organisms

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9
Q

Post splenectomy abx prophylaxis

A

Pen V

2 years/until 16 yo

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10
Q

Meningitis pathogens in 0-3 mo

A
  • group B strep
  • listeria
  • E coli
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11
Q

Meningitis pathogens in 3mo -6yrs

A
  • n menigitidis
  • strep pneumonia
  • H infuenza
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12
Q

Meningitis in 6-60yo

A
  • n meningitidis
  • ## strep pneumonia
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13
Q

over 60 yo pathogens for meningitis

A

strep pneumonia
n meningitidis
listeria

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14
Q

immunocompromised pathogens for meningitis

A

listeria

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15
Q

Infectious mononucleosis

A

Glandular fever

EBV (HHV-4)

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16
Q

Dx of glandular fever

A
  • heterophil antibody test (Monospot test)

- FBC and Monospot in the second week.

17
Q

Reaction of EBV to penicillin

A

Widespread rash

18
Q

Chicken pox pathogen

A

VZV

19
Q

Chickenpox infectivity?

A

4 days before start of rash

to 5 days after the first day

20
Q

CLL blood film

A

smear cells:

smuldge b cells

21
Q

Reaction to amox

A

Rash with infectious mononucleosis

22
Q

Reaction to co-amox

A

chlestasis

23
Q

Reaction to flucloxacillin

A

cholestasis

24
Q

Reaction to erythromycin

A

GI upset

Prolonged QT

25
Q

Reaction to cipro

A

Lower seizure threshold

Tendonitis

26
Q

Reaction to met

A

Reacts to alcohol

27
Q

Reaction to doxycycline

A

Photosensitivity

28
Q

Reaction to trimethoprim

A

Photosensitive rash
Pruritus
Suppression of haematopoiesis

29
Q

Myeloma blood film

A

rouleaux formation

30
Q

The M rule for primary biliary cirrhosis

A

IgM
AMA
Middle aged females

31
Q

Types of hodgkin

A

Noular Sclerosing most common
Mixed cellularity
Predominant lymphocyte best prognosis
Lymphocyte depleted worst prognosis

32
Q

Aurorods

A

AML

33
Q

Positive EMT

A

Heridatory spherocytosis

34
Q

Direct anti globulin test

A

Autoimmune haemolytic reaction

35
Q

Beri beri

A

Thiamine deficiency
Dry PNS sx
Wet CVS sx

36
Q

HbA2 high

A

Beta thalasaemia

Passmed (5 decks)

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