PATH Flashcards
Burkit histological feature
starry sky sign: lymphocyte sheets interspersed with macrophages containing dead apoptotic tumour cells
Burkit risk factors?
EBV
c-myc
How myeloma cause hyperviscosity?
high paraprotein levels cause hyperviscosity: high risk of stroke
Why high calcium level in myeloma
Myeloma cells release TNF/ IL1 which cause osteoclastic activity
Blood film for myelofibrosis
tear drop poikilocytes
Blood film for iron deficiency anaemia
pencil shape poikilocytes
target cells
Blood film for hyposplenism
target cells Howell-Jolly bodies Pappenheimer bodies siderotic granules acanthocytes
Splenectomy pathogens susceptibility
pneumococcus,
Haemophilus,
meningococcus
Capnocytophaga canimorsus (dog bite)
Typically occurs with encapsulated organisms
Post splenectomy abx prophylaxis
Pen V
2 years/until 16 yo
Meningitis pathogens in 0-3 mo
- group B strep
- listeria
- E coli
Meningitis pathogens in 3mo -6yrs
- n menigitidis
- strep pneumonia
- H infuenza
Meningitis in 6-60yo
- n meningitidis
- ## strep pneumonia
over 60 yo pathogens for meningitis
strep pneumonia
n meningitidis
listeria
immunocompromised pathogens for meningitis
listeria
Infectious mononucleosis
Glandular fever
EBV (HHV-4)
Dx of glandular fever
- heterophil antibody test (Monospot test)
- FBC and Monospot in the second week.
Reaction of EBV to penicillin
Widespread rash
Chicken pox pathogen
VZV
Chickenpox infectivity?
4 days before start of rash
to 5 days after the first day
CLL blood film
smear cells:
smuldge b cells
Reaction to amox
Rash with infectious mononucleosis
Reaction to co-amox
chlestasis
Reaction to flucloxacillin
cholestasis
Reaction to erythromycin
GI upset
Prolonged QT
