Path

Question 1

benign tumor of the epithelium (2)

Answer 1

adenoma, papilloma

Question 2

benign tumor of the mesenchyme

Answer 2

lipoma

Question 3

benign tumor of lymphocytes

Answer 3

does not exist

Question 4

benign tumor of melanocyte

Answer 4

nevus (mole)

Question 5

malignant tumor of epithelium (two)

Answer 5

adenocarcinoma, papillary carcinoma

Question 6

malignant tumor of mesenchyme

Answer 6

liposcarcoma

Question 7

malignant tumor of lymphocyte

Answer 7

lymphoma/leukemia

Question 8

malignant tumor of melanocyte

Answer 8

melanoma

Question 9

normal kappa to lambda light chain ratio

Answer 9

3:1

Question 10

cancer assoc with aflatoxins

Answer 10

hepatocellular carcinoma

Question 11

aflatoxins are derived from which bacterial infection that contaminates stored rice and grains

Answer 11

aspergillus

Question 12

cancer assoc with alkylating agents

Answer 12

leukemia/lymphoma

Question 13

leukemia/lymphoma can be a side effect of what type of medical treatment

Answer 13

chemo

Question 14

cancer assoc with alcohol (2)

Answer 14

squamous cell carcinoma of oropharnyx and upper esophagus, hepatocellular carcinoma

Question 15

cancer assoc with arsenic (present in cigarette smoke) (3)

Answer 15

squamous cell carcinoma of skin, lung cancer, angiosarcoma of liver

Question 16

2 cancer assoc with asbestos

Answer 16

lung cancer, mesothelioma (more likely lung cancer)

Question 17

4 cancer assoc with cigarette smoke

Answer 17

carcinoma of oropharynx, esophagus, lung, kidney bladder pancreas

Question 18

polycyclic hydrocarbons are particularly carcinogenic. they’re found in:

Answer 18

cigarette smoke

Question 19

cancer assoc with nitrosamines (found in smoked foods)

Answer 19

stomach carcinoma (high rates in Japan)

Question 20

cancer assoc with naphthylamine

Answer 20

urothelial carcinoma of bladder

Question 21

cancer assoc with vinyl chloride (PVC pipes)

Answer 21

angiosarcoma of liver

Question 22

cancer assoc with nickel, chromium, beryllium, silica

Answer 22

lung carcinoma (occupational exposure)

Question 23

cancer assoc with EBV (3)

Answer 23

nasopharyngeal carcinoma, Burkitt lymphoma, CNS lymphoma in AIDS

Question 24

cancer assoc with HHV-8

Answer 24

Kaposi sarcoma

Question 25

cancer assoc with HBV and HCV

Answer 25

hepatocellular carcinoma

Question 26

cancer assoc with HTLV-1

Answer 26

adult T cell leukemia/lymphoma

Question 27

Multiple cancer assoc with high risk HPV

Answer 27

squamous cell carcinoma of vulva, vagina, anus, cervix, adenocarcinoma of cervix

Question 28

3 cancer assoc with ionizing radiation (nuclear reactor accidents and radiotherapy)

Answer 28

AML, CML, papillary carcinoma of thyroid (generates hydroxyl free radicals)

Question 29

3 cancer assoc with nonionizing radiation (UVB sunlight)

Answer 29

basal cell carcinoma, squamous cell carcinoma, melanoma of skin

Question 30

tumor associated with platelet derived growth factor

Answer 30

astrocytoma via overexpression/autocrine loop

Question 31

tumor associated with amplification of epidermal growth factor receptor ERBB2 (HER2/neu)

Answer 31

subset of breast carcinoma

Question 32

tumor associated with point mutation in neural growth factor receptor RET

Answer 32

MEN 2A, MEN 2B, sporadic medullary carcinoma of thyroid

Question 33

tumor associated with point mutation in stem cell growth factor receptor KIT

Answer 33

GI stromal tumor

Question 34

3 tumor associated with point mutation in GTP-binding protein RAS

Answer 34

carcinomas, melanoma, lymphoma

Question 35

2 tumor associated with t(9;22) with BCR tyrosine kinase ABL

Answer 35

CML and some types of ALL

Question 36

tumor associated with t(8;14) involving IgH c-MYC txn factor

Answer 36

Burkitt lymphoma

Question 37

tumor associated with amplification of N-MYC txn factor

Answer 37

neuroblastoma

Question 38

tumor associated with amplification of L-MYC txn factor

Answer 38

lung carcinoma (small cell)

Question 39

tumor associated with t(11;14) involving IgH cyclin CCND1

Answer 39

mantle cell lymphoma (follicle-mantle-margin)

Question 40

tumor associated with amplification of CDK4 cyclin dependent kinase

Answer 40

melanoma

Question 41

immunohistochemical stain which intermediate filaments associated with epithelium

Answer 41

keratin

Question 42

immunohistochemical stain which intermediate filaments associated with mesenchyme

Answer 42

vimentin

Question 43

immunohistochemical stain which intermediate filaments associated with muscle

Answer 43

desmin

Question 44

immunohistochemical stain which intermediate filaments associated with neuroglia

Answer 44

GFAP

Question 45

immunohistochemical stain which intermediate filaments associated with neurons

Answer 45

neurofilament

Question 46

immunohistochemical stain PSA--associated with what type of tissue?

Answer 46

prostatic epithelium

Question 47

immunohistochemical stain ER--associated with what type of tissue?

Answer 47

breast epithelium

Question 48

immunohistochemical stain thyroglobulin--associated with what type of tissue?

Answer 48

thyroid follicular cells

Question 49

immunohistochemical stain chromogranin--associated with what type of tissue?

Answer 49

neuroendocrine cells (small cell carcinoma of lung and carcinoid tumors) HIGH YIELD

Question 50

immunohistochemical stain S-100--associated with what 3 type of tissue?

Answer 50

melanoma, Schwannoma and Langerhans cell hisiocytosis

Question 51

Bcl(1/2): cyclin gene

Answer 51

Bcl1

Question 52

(Bcl2/IL2): anti apoptosis

Answer 52

Bcl2

Question 53

(IL2/Lyn): growth factor

Answer 53

IL2

Question 54

(Lyn/K-Ras): tyrosine kinase

Answer 54

Lyn

Question 55

(K-Ras/p53): GTP binding protein gene

Answer 55

K-RAS

Question 56

(NMYC/p53): DNA damage response

Answer 56

P53

Question 57

(BCL1/NMYC): txt factor

Answer 57

NMYC