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Anatomy (AIM) > Path 2 > Flashcards

Path 2 Flashcards

1
Q

epithelial - malignant

A

-carcinoma

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2
Q

mesenchymal - malignant

A

-sarcoma

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3
Q

hamartoma

A

Benign.

Right place, but disorganized.

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4
Q

heteropia/choristoma

A

benign
wrong place
ectopic rest of normal tissue

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5
Q

incidence of cancers in children

A

1) leukemia
2) brain
3) lymphoma

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6
Q

tumor suppressor genes

A 
Rb - retinoblastoma, sarcoma
p53 - many
BRCA - breast, prostate, ovarian
APC - colon
NF1 - neurofibromas
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7
Q

proto-oncogenes

A 
abl 
ras 
HER2 
EGFR
c-myc
bcl-2
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8
Q

Rb

A

TSG

retinoblastoma, sarcomas

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9
Q

BRCA

A

TSG

breast, prostate, ovarian

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10
Q

p53

A

TSG

many common cancers

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11
Q

APC

A

TSG

colon cancer

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12
Q

NF1

A

TSG

neurofibromas

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13
Q

abl

A

proto-oncogene

CML

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14
Q

ras

A

proto-oncogene

colon

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15
Q

HER2

A

proto-oncogene

breast, ovarian, gastric

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16
Q

EGFR

A

proto-oncogene

lung

17
Q

c-myc

A

proto-oncogene

Burkitt’s lymphoma

18
Q

bcl-2

A

proto-oncogene

lymphoma

19
Q

common distant mets for liver

A 
Colon
Stomach
Pancreas
Breast
Lungs
20
Q

common distant mets for brain

A 
Lung
Breast
Melanoma
Kidney
GI tract
21
Q

common distant mets for bone

A 
Breast/prostate
Lung
Kidney
Thyroid 
Testis
22
Q

common distant mets for peritoneum

A 
Ovary
Primary
Breast
Appendix
Melanoma
23
Q

dysplasia vs atypical hyperplasia

A

dysplasia: cervical/Gi/GU/respiratory epithelial

atypical hyperplasia: breast endometrial

24
Q

IHC stains for neoplasms

A 
CK: epithelial
S-100: neuroendocrine
LCA: lymphocytic marker
Chromogranin: neuroendocrine
Vimentin: soft tissue/sarcoma
25
Q

CK

A

epithelial IHC

26
Q

S-100

A

neuroendocrine IHC

27
Q

LCA

A

lymphocytic marker IHC

28
Q

chromogranin

A

neuroendocrine IHC

29
Q

vimentin

A

soft tissue/sarcoma IHC

30
Q

PSA

A

serum tumor marker for prostate CA

31
Q

CEA

A

serum tumor marker for colorectal, pancreatic, gastric, breast

32
Q

CA-125

A

serum tumor marker for for ovarian

33
Q

AFP

A

serum tumor marker for hepatocellular

34
Q

lung squamous cell CA

A

PTH

hypercalcemia

35
Q

lung small cell CA

A

ACTH

Cushing Syndrome

Anatomy (AIM) (13 decks)

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