Pastest Orthopaedic For The MRCS Part A Flashcards
Define seronegative Spondyloarthritis?
A group of disorders,characterised by
(1) Seronegative inflammatory arthritis or spondylitis
(2) primarily affect the spine and the sacroiliac joints.
True or False: Spondyloarthritis can lead to fusion of the spine.
True
Name one common symptom of Spondyloarthritis.
Chronic lower back pain and stiffness (sacroiliitis)
Fill in the blank: Spondyloarthritis is often associated with the _____ gene.
HLA-B27
What are the main types of Seronegative Spondyloarthritis?
Mnemonic;RAPE
(1) Ankylosing spondylitis,
(2) psoriatic arthritis,
(3) reactive arthritis, and
(4) enteropathic arthritis.
Multiple choice: Which of the following is NOT a characteristic of Spondyloarthritis?
A) Enthesitis
B) Dactylitis
C) Osteoporosis
D) Hyperuricemia
D) Hyperuricemia
What is the typical age of onset for Spondyloarthritis?
15-40 yrs in most Seronegative spondyloartheritis
True or False: Spondyloarthritis primarily affects women more than men.
False (males are 3-5 times more than females,i.e.,3-5 times more common in males)
What is enthesitis?
Inflammation of the entheses, the sites where tendons or ligaments insert into the bone.
Fill in the blank: Patients with Spondyloarthritis may experience _____, which is swelling of fingers or toes.
Dactylitis
What imaging technique is commonly used to assess Spondyloarthritis?
1st/ XRs
-Indications: (1) Sacroiliitis
(2) Inflammatory spinal pain
(≥ 3 months)
(3) Limited spinal movements
(4) Limited chest expansion
- Changes: in the following successive order
(1) Blurred joint margins
(2) Subchondral erosion
(3) Sclerosis or fusion of the sacroiliac joint
(4) Loss of lumbar lordosis ( Loss of lumbar lordosis with
restriction of movements in a young pt are highly
suggestive of ankylosing spondylitis)
(5) Bamboo spine ( the latest sign)
2nd/MRI
- Indications: Early stages of Ankylosing spondylitis (as changes may take many years to become evident on XRs)
Which medication class is commonly used for treating Spondyloarthritis?
Non-steroidal anti-inflammatory drugs (NSAIDs)
True or False: Spondyloarthritis can affect organs outside the musculoskeletal system.
True
What is the role of TNF-alpha inhibitors in Spondyloarthritis treatment?
1) reduce inflammation and
2) improve symptoms.
Multiple choice: Which condition is commonly associated with Spondyloarthritis?
A) Ulcerative colitis
B) Diabetes
C) Asthma
D) Hypertension
A) Ulcerative colitis
What is the primary genetic marker associated with Spondyloarthritis?
HLA-B27 antigen
Fill in the blank: Spondyloarthritis is characterized by _____ involvement and may lead to spinal stiffness.
Axial
What is reactive arthritis?
A form of Spondyloarthritis that occurs following an infection in another part of the body.
True or False: Spondyloarthritis can lead to cardiovascular complications.
True (aortic and non aortic valve disease,congestive heart failure,arrhythmias)
What lifestyle modification can help manage Spondyloarthritis symptoms?
1) Regular exercise and
2) physical therapy.
What is the significance of the Schober test in Spondyloarthritis?
It assesses lumbar spine mobility.
Multiple choice: Which of the following is a key feature of Ankylosing Spondylitis?
A) Asymmetric joint involvement
B) Bamboo spine
C) Rheumatoid nodules
D) Morning stiffness
B) Bamboo spine
What is the term for inflammation of the eye associated with Spondyloarthritis?
Uveitis
Fill in the blank: The presence of _____ is a diagnostic criterion for Ankylosing Spondylitis.
Sacroiliitis
What is the typical course of Spondyloarthritis?
It is a chronic condition that can fluctuate in severity.
What a plain XRs shows in psoriatic arthritis?
Osteolysis around joints
Define Ankylosing spondylitis
What are the general features of Ankylosing spondylitis?
Mnemonic; SAC
(1) Systemic
(2) Autoimmune
(3) Chronic
What is the characteristic classical triad of Ankylosing spondylitis ?
Discuss the incidence of Ankylosing spondylitis ?
What is incidence of Ankylosing spondylitis in 1st degree relatives?
What is the incidence of Ankylosing spondylitis in identical twins?
What is the concordance rate of Ankylosing spondylitis in identical twins?
What does it mean that the concordance rate of Ankylosing spondylitis in identical twins is 50%?
Environmental factors may also contribute
What is the prevalence of Ankylosing spondylitis ?
0.1%
What is the aetiology of Seronegative spondyloartheritis?
Poorly understood,but it is thought to have a strong association (≈ 90%) with HLA-B27
Discuss pathogenesis of Ankylosing spondylitis?
What is the role of microorganisms in Ankylosing spondylitis?
Give 2 examples of how microorganisms get into the body in the pathogenesis of Ankylosing spondylitis
Barrier damage to the
(1) Skin in psoriasis
(2) Bowel in IBD
What is the role of the microtrauma in the pathogenesis of Ankylosing spondylitis?
What is the role of HLA-B27 in the pathogenesis of ankylosing spondylitis?
What is the percentage of HLA-B27 in pts from general population with ankylosing spondylitis?
90%
What is the percentage of HLA-B27 in 1st degree relatives with ankylosing spondylitis?
20%
What is the main genetic predisposition in white pts with ankylosing spondylitis?
HLA-B27
What is the main genetic predisposition in black pts with ankylosing spondylitis?
HLA-B7
What does the prevalence of HLA-B27 in white people and HLA-B7 in black people with ankylosing spondylitis indicate?
Supports a genetic predisposition
What are the C/P of ankylosing spondylitis?
What are the intrarticular clinical features of ankylosing spondylitis?
What is the site of the pain in ankylosing spondylitis?
Lower back pain [sacroiliitis]
What is the onset of the pain in ankylosing spondylitis?
Insidious
What is the character or feature of the pain in ankylosing spondylitis?
The main feature
What is the time of the pain in ankylosing spondylitis?
Early morning or nocturnal
What is associated with the pain in ankylosing spondylitis?
Mnemonic; SPEBSALR
What is the significance of the presence of loss of lumber lordosis and restriction of spinal movement in a young pt?
Highly suggestive of ankylosing spondylitis
What are the most common joints affected by peripheral arthritis in ankylosing spondylitis?
Affects larger joints:
1) Hip joint
2) Knee joint
3) Ankle joint
What is the incidence of peripheral artheritis in ankylosing spondylitis?
35%
What is the main feature of peripheral arthritis in ankylosing spondylitis?
Symmetrical
What aggravates the pain in ankylosing spondylitis?
Rest
What relieves the pain in ankylosing spondylitis?
Exercise or movement
Give examples of the extra-articular clinical features of ankylosing spondylitis
Mnemonic; UA/IP or PIA/U
What is the differential diagnosis of ankylosing spondylitis?
What are the investigations of ankylosing spondylitis?
What are the blood investigations of ankylosing spondylitis?
What is the significance of detecting HLA-B27 when investigating for ankylosing spondylitis ?
What is the significance of checking CBC when investigating for ankylosing spondylitis ?
Anaemia
What is the status of ALP when investigating for ankylosing spondylitis?
Increased
What are the radiological types of ankylosing spondylitis?
What is the characteristic feature of radiographic axial spondyloartheritis?
Characterised by SACROILIITIS on XRs
What is the characteristic feature of non radiographic axial spondyloartheritis?
Axial spondyloartheritis in the absence of XRs changes
What are the radiological diagnostic features of ankylosing spondylitis on the XRs?
What is the speciality for which we refer pts with ankylosing spondylitis?
Rheumatologist
Discuss treatment of ankylosing spondylitis
What is the non pharmacological treatment of ankylosing spondylitis?
What is the role of regular exercise in the treatment of ankylosing spondylitis?
What is the pharmacological treatment of ankylosing spondylitis?
What is the role of NSAIDs in the treatment of ankylosing spondylitis?
Symptomatic pain relief
What is the indication of DMARDs or steroids in the treatment of ankylosing spondylitis?
If the disease is refractory to NSAIDs
What is the drawback of using DMARDs or steroids in the treatment of ankylosing spondylitis?
Sulfasalazine or methotrexate may help peripheral arheritis but have no impact on spinal disease
Give 2 examples of the DMARDs used in the treatment of ankylosing spondylitis
1) Sulfasalzine
2) Methotrexate
What is the indication of anti-TNF-α in the treatment of ankylosing spondylitis?
What is the mechanism of action of anti-TNF-α in the treatment of ankylosing spondylitis?
Discuss surgical treatment of ankylosing spondylitis?
What is the indication of surgical treatment of ankylosing spondylitis?
What are the types of procedures of surgical treatment of ankylosing spondylitis?
Discuss prognosis of ankylosing spondylitis
What is the course of ankylosing spondylitis?
What affects quality of life in ankylosing spondylitis ?
What are the factors that affect prognosis of ankylosing spondylitis?
What are the complications of ankylosing spondylitis?
Give examples of ophthalmic complication of ankylosing spondylitis?
Anterior uveitis
Give examples of orthopaedic complications of ankylosing spondylitis?
1) Osteoporosis
2) Spinal fractures and spinal cord injury
3) Hip involvement
Give examples of cardiac complications of ankylosing spondylitis?
1) Valve disease (aortic and non aortic)
2) Congestive heart failure
3) Arrhythmias
What is the C/P of cauda equina syndrome?
1) Sudden onset of pain in the lower limbs
2) Loss of bladder and bowel control
What is the main cause of cauda equina?
Any condition that causes narrowing canal and compresses lower nerve roots
What is the treatment of cauda equina?
It is a surgical emergency and requires emergent decompression
What is the most common site for spinal disc herniation?
L4-L5 or L5-S1 discs
What is the C/P of spinal disc herniation?
Presentation may vary depending upon the level and severity of nerve root compression.
Loss of lumbar lordosis may occur due to spasm and contraction of paravertebral muscles
What is the diagnostic test for spinal disc herniation?
MRI
What is the treatment of spinal disc herniation?
Depending upon severity of the disease
1) Conservative
2) Surgical