Past papers midt 2 1st semester Flashcards
in Wegener granulomatosis :
a. ) large elastic arteries are affected
b. ) small to medium sized arteries are affected
c. ) autoantibodies against endothelial cells are present
d. ) C-ANCA antibodies are present
B and D
- ) characteristic for Wegener granulomatosis
a. ) multifocall necrotizing pulmonary artery granulomas (lung)
b. ) myocardial infarction (heart is rarely effected)
c. ) focal necrotizing thrombogenic vasculitis of isolated glomeruli (kidney)
d. ) good prognosis if untreated
A, C
- ) Wegener triade in wegerners granulomatosis
a. ) granulomas, vasculitis , pulmonary involvement
b. ) granulomas , respiratory tract involvement , glomerulonephritis
c. ) granulomas, vasculitis of small and medium sized arteries , glomerulonephritis
d. ) granulomas, vasculitis, myocardial infaction
B
- ) difference between giant cell arteritis and takayasu arteritis (2correct)
a. ) granuloma formation in giant cell arteritis (characterizes it)
b. ) giant cell arteritis affects people over 50 (>55y)
c. ) progressive luminal narrowing in takayasu arteritis
d. ) pulmonary involvement in takayasu arteritis
B, C
- ) which vasculitis is also called the pulsless disease
a. ) giant cell arteritis because its granulomas limit blood flow
b. ) polyarteritis nodosa because renal involvement decreases blood pressure
c. ) Kawasaki diseases bc aneurysm formation decreases blood flow
d. ) Takayasu arteritis weakens the pulse of the upper extremities
D
157.)
the aorta of young women is affected by :
a.) polyarteritis nodosa
b.) Takayasu arteritis (usually Asians)
c.) Crohn citizens
d.) Raynauds syndrome ( upper limb veins !)
e.) syphilitic andarteritis obliterans
B
- ) which vasculitis type is NOT associated wth ANCA antibodies ? ( 2 correct )
a. ) Wegener granlomatosis
b. ) Microscopic polyarteritis
c. ) polyarteritis nodosa
d. ) Chrug strauss
e. ) giant cell arteritis
C, E
- ) polyarteritis nodosa (2 correct) :
a. ) commonly in women
b. ) pulmonary involvement
c. ) pronounced renal involvement
d. ) affect the whole arterial tree
e. ) is a segmental transmural necrotizing inflammation
C,E
- ) characteristic for polyarteritis nodosa ( 2 correct):
a. ) granuloma formation
b. ) ANCA antibodies and ADCC ( antibody dependent cellular cytotoxicity)
c. ) mainly affects vessels of : kidney , heart , liver and GI
d. ) rapid hypertension due to renal a. involvement
C,D
161.) leads to polyarteritis nodosa a.) contraceptives b.) heavy smoking c.) greasy food d.) strong alcoholism e.) congenital heart diseases
B
- ) histological appearance of polyarteritis nodosa (2correct)
a. ) in elastic arteries
b. ) fibrinoid necrosis of small arteries
c. ) in muscular arteries
d. ) in large arteries
B, C
163.)
characteristic for polyarteritis nodosa EXCEPT :
a.affects small to medium sized vessels
b.most frequently in middle age
c.affects lungs
d. acute necrotic arteriolitis affecting all vessel wall layers
C
most frequent in young adults
- ) kindey biopsy can diagnose this diseases EXCEPT :
a. ) Wegener granulomatosis
b. ) amyloidosis
c. ) arteriosclerosis
d. ) giant cell arteritis
e. ) polyarteritis nodosa
D
characteristic for Kawasaky disease: ( 2correct)
a. in the aorta of young women
b. in childhood (under five years old)
c. primarily involves renal arteries
d. primarily involves coronary arteries (can cause aneurysm)
B, D
possible complication of kawasaky disease ( 2 correct) : a.coronary aneurysm , rupture and thrombosis
b. malignant hypertension
c. conjunctival and oral erythema
d. blindness
A, C
167.) muscle cells ?
Which vasculitis is associated with autoantibodies against endothelial and smooth muscle cells ?
a.) Wegener granulomatosis (ANCA antibodies)
b.) microscopic polyarteritis (same)
c.) kawasaky disease
d.) chrug strauss (same)
C
- ) characteristic for microscopic polyangiitis ( 2correct):
a. ) affects large muscular arteries
b. ) affects segments of small arteries , capillaries and venules
c. ) all arterial lesions are of the same age
d. ) coronary artery thrombosis
B, C
169.) causes of microscopic polyangiitis ( 3correct) :
a.) peniciline and sulfamide induced necrotizing arteritis
b.) food hypersensitivity
c.) PLANCA antibodies against offending agent ( here we talk about RBCs with absorbed
peniciline ! )
d.) secondary to henoch schönlein purpura
A,C,D
- ) possible complications of microscopic polyangiitis ( 2 correct) :
a. ) necrotizing glomerulonephritis
b. ) myocardial infarction
c. ) necrotizing pulmonary arteritis
d. ) macroscopic infactions
X (A,C)
- ) characteristic for infectious vasculitis
a. ) caused by viral infections
b. ) caused by direct invasion of vessel wall by bacteria and fungi
c. ) can lead to malignant hypertension
d. ) can lead to myotic aneurysm (aneurysm caused by bacterial infection)
B,D
Raynauds phenomen occurs in :
a. liver
b. brain
c. carpal tunnel
d. vessels of upper extremities (hands)
E
cardiac Raynaud phenomen
a. stenotic event that always leads to myocardial infarction
b. caused by hyperactivity of medial smooth muscle in the coronary arteries
c. caused by mechanical vessel wall damage
d. results in coronary vasospasm that may lead to myocardial infarction when prolonged
B,D
what histological change explains aortic aneurysm in syphilis
a. ) calcification
b. ) cystic meial necrosis
c. ) direct lysis of tunic media by endotoxin
d. ) endarteritis of vasa vasorum
e. ) fatty streak
D
175.) complication of arteriolosclerosis EXCEPT:
a.) thrombosis
b.) median necrosis
c.) ischemic organ damage
d.) aneurysm
e.) embolization
arteriolosclerosis : vesselhardening due to hyaline accumulation in media/intima , no thrombus / plaque wthatsoever
E
- ) important factor in atherosclerosis EXCEPT :
a. ) hypertension
b. ) lipid deposition in vessel wall
c. ) endothelial destruction
d. ) hyperglacemia
e. ) amyloid deposition in vessel wall
E
177.)
not true for an aneurysm :
a.) within the lumen there is frequent thrombosis
b.) the lumen shows eccentric thinning
c.) occurs in arteries
d.) is a circumscribes alteration of the vessel wall
e.) the elastic fibers in the vessel wall are diminished
X
But someone says E
- ) an unstable atheromatous plaque contains more lipid than a stable one
a. true
b. false
A
180.)
Chracteristic for Eisenmenger syndrome : (2 correct)
a.) includes ASD , VSD and patent ductus ateriosus
b.) shunt reversal of an left to right or right to left shunt
c.) isolated vessel transposition ( its lethal !)
d.) can be seen in ASD, VSD and patent oval formen
B,D
- ) PDA (patent ductus arteriosus) :
a. ) normally closes in response to O2, PGE2 and increasing pulmonary resistance
b. ) normally closes in response to O2 , PGE2 and decreasing pulmonary resistance
c. ) is closed prematurely in hypoxic neonates
d. ) its closure is delayed or inhibited in hypoxic neonates
B, D
- ) Tetralogy of fallot includes :
a. ) ASD, subpulmonic stenosis , aortic obstruction by ASD , right ventricular dilation
b. ) VSD, subpulmonic stenosis , overriding of the VSD by the aorta , right ventricle dilation
c. ) VSD , subpulmonic stenosis , overriding of the VSD by the aorta , right ventricle hypertrophy
d. ) ASD, VSD , pulmonic stenosis and right atrial dilation
C
A man is pulsless at the popliteal arteries, hypertensive in the upper extremities, has a history of stroke , suffers from pain during intense walking
a. ) coarctation of aorta
b. ) venstricular septal defect (VSD)
c. ) atrial septal defect (ASD)
d. ) transposition of the great vessels
A
which alteration does not belong to the tetralogy of fallot ?
a. pulmonary stenose
b. overriding of aorta
c. right heart hypertrophy
d. ventricular spetal defects
e. left heart hypertrophy
E
most common cardiac congenital malformation is pulmonary stenosis
a. true
b. false
B
what is NOT a result of right ventricular failure ?
a. splenomegaly
b. ascites
c. pulmonary edema
d. edema in leg
e. nutmeg liver
C (left ventricular failure)
typical sign of left ventricular heart failure is edema in region of the ankles
a. true
b. false
B (it is typical for right sided heart failure , left sided is generalized both sided edema)
mitral stenosis leads to (2correct)
a. left ventricular dilation
b. left atrial dilation
c. pulmonary edema
d. right ventricular hypertrophy
B,C
D ( chronic only ! )
possible consequence of mitral stenosis ( 2correct)
a. left ventricular hypertrophy
b. atrial fibrillation
c. pulmonary hypertension
d. aortic aneurism
B, C
possible cause of left ventricular failure : (2correct )
a. ) pulmonary fibrosis
b. ) pulmonary embolism
c. ) hypertension
d. ) aortic insufficiency
C,D
tendency for mitral valve prolapse is genetically inherited a. true
b. false
A
changes in a mitral valve insufficiency EXCEPT :
a. ) dilation of the right atrium
b. ) dilation of the right ventricle
c. ) dilation of the left ventricle
d. ) slight atrophy of the right ventricle
e. ) sclerosis of the pulmonary artery
D (atrophy: shrinkage of cell)
cause of aortic stenosis ? ( 2 correct )
a. calcification
b. hemochromatosis
c. rheumatic endocarditis
d. amyloidosis
A,C
forms of aortic coarctation are : infantile , adult and intermediate
true
false
false ( only infantile and adult ??)
- ) Leads to chronic core pulmonale
a. ) lobar peumonia
b. ) thromboembolism of pulmonary veins
c. ) pulmonary edema
d. ) bronchiopneumonia
e. ) emphysema
e
b (acute core pulmonale if saddle embolus)
- ) cause of core pulmonale ( 2 correct)
a. ) hypercholestermia
b. ) sever kyphoscoliosis
c. ) cirrhosis
d. ) chronic obstructive lung diseases
B,D
- ) cause of hydrothorax :
a. ) acute core pulmonale
b. ) pulmonary embolism
c. ) acute left ventricular failure
d. ) hypertension
e. ) chronic right heart failure
E ( congestion of pleural veins -> plasma filtration in pleural
space )
which process most frequently leads to enlarged heart size ?
a. dysplasia
b. metaplasia
c. hyperplasia
d. atrophy
e. hypertrophy
E
heart diseases often leading to hydrothorax ( 2correct )?
a. chronic pericarditis
b. dilative cardiomyopathy
c. atrial appendage thrombosis
d. core pulmonlae chronicus
B (decreased CO L> venous congestion –> pleural vein congestion), D
in dilative cardiomyopathy : spherical dilation and mural thrombosis of the left ventricle are typical
a. ) true
b. ) false
True
in which diseases is the heart abnormally enlarged but the number of myocytes is unchanged?
a. ) atrophy
b. ) hypertrophy
c. ) dysplasia
d. ) anaplasi
B
- ) not common in right ventricular hypertrophy
a. ) ascites
b. ) pulmonary edema
B (left ventricular hypertrophy)
A - and systemic edema etc
203.)
left dilative cardiomyapthy is : ( 2correct )
a.) associated with decreasing contractility and atrophy
b.) associated with decreasing contractility and optional hypertrophy
c.) due to a XLlinked dystrophin mutation
d.) associated wth tricuspid valve regurgitation
B,C
- ) which statement is characteristic for cardiomyopathy ?
a. ) is associated with an inflammatory infiltration
b. ) heals within a short time
c. ) is slowly progressing
d. ) has no long term consequences
e. ) leads to fast cardiac failure
C
- ) in hypertrophic cardiomyopathy ( 2 correct) :
a. ) the myocardium shows hypertrophy and dilation
b. ) the myocardium shows eccentric hypertrophy of the ventricular spetum
c. ) there is a right outflow tract obstruction due to septal enlargement ( left !)
d. ) there is marked myocardial hypertrophy and interstitial fibrosis
B,D
- ) hypertrophic cardiomyopathy leads to
a. ) increased contractility and cardiac oputput
b. ) decreased contractility and cardiac output ( predisposing to IHD!! )
c. ) systolic dysfunction ( impaired contraction)
d. ) diastolic dysfunction (impaired relaxation)
B,D
- ) Restrictive cardiomyopathy (2 correct) :
a. ) Idiopathic (often unknown) or due to irradiation fibrosis , sarcoidosis, amyloidosis
b. ) decreased cardiac output
c. ) decreased cardiac contractility
d. ) decreased cardiac compliance and ventricular filling
A,D
- ) Löfflers endomyocarditis ( 2 correct) :
a. ) associated with sarcoidosis
b. ) associated with cardiac fibrosis and thrombosis
c. ) associated with lymphocytic infiltration
d. ) associated with eosinophilic infiltration ( pulmonary eosinophilia = löfflers sign!)
B,D
- ) peniciline can cause myocarditis
a. ) true
b. ) false
true (hypersensitive myocarditis
210.)
rheumatic arthritis / endocarditis is due to an infectious disease
a.) ture
b.) false
false ( post streptoccal sequel but the process itself is nonLinfectious ( Antibody mediated – autoimmune disease)
211.) ischemic heart disease :
a.) imbalance between cardiac perfusion and myocardial O2 demand leading to
myocardial ischemic injury
b.) common endpoint of many cardiac diseases
c.) commonly results from hematogenous diseases impairing coronary blood flow
d.) is unrelated to congestive heart failure
A,C
Congestive heart failure:
a. imbalance between cardiac perfusion and myocardial O2 demand leading to myocardial ischemic injury
b. heart is unable to maintain a CO sufficient to meet metabolic demands of the myocardium which results in ishemic myocardial injury
c. heart is unable to maintin a CO sufficient to meet metabolic demands of downstream tissue which results in systemic hypoperfussion
d. is the common endpoint of most cardiac diseases
C,D
Prinzmetal Angina is a consequence of brain spasms.
true
false
false ( coronary spasm !)
macroscopic appearance of an ischemic heart disease EXCEPT :
a. core pulmonale
b. chronic ishemic heart disease
c. angina pectoris
d. heart infarct
e. sudden cardiac death
A
215.) which microscopic lesion is characteristic for chronic myocardial ischemia ? a.interstitial fibrosis b.granulocytic infiltration c.granuloma d.apoptosis
A
- ) What worsens ischemic cardiac diseases?
a) left ventricular hypertrophy
b) tachycardia
c) anemia
d) bradycardia
A,B,C
fatty degeneration of the myocardium
a. lipomatosis of the heart
b. the late stadium of a myocardial infarction
c. amyloidosis of the myocardium
d. scaring due to rheumatic myocarditis
e. a fine linear hypoxic small dropLlike steatosis
E
what leads to an acute myocardial infarction ( 2correct)
a. ) abdominal aortic aneurysm
b. ) coronary thrombosis
c. ) severe anemia
d. ) temporal arteriti
B,C
219.) how much time does it need for VISIBLE macroscopic changes in the myocardium after a myocardial infarction ? a.) 12L18h (12 – 24 hrs) b.) 1day c.) 6days d.) 6weeks
A
220.) in the area of the myocardial infarction a scar (macroscopic) develops : a. in 7814 days b. in 4 weeks c. in 283 days d. in 587 days e. in 2L3weeks
E
Due to MI the following micro- and macroscopic changes can be seen until postLinfarction day 20 EXCEPT :
a. ) coagulation necrosis
b. ) hemorrhagic edges
c. ) pearl like pale scar tissue
d. ) capillary granulation tissue
e. ) progressively decreasing area of the infarct
D
organisation of necrotic area in a myocardial infarction starts :
a. after 5 days
b. after 12 hrs
c. after 1 month
d. after 2 weeks
A
possible form of acute myocardial infarction ( 2correct)
a. isolated right ventricular
b. transmural
c. pericardia
d. subendocardial
B,D
typical change is :
in case of a 3 vessel stenosis ( high grade atherosclerosis in all 3 coronary arteries )
a.) transmural posterior infarction
b.) transmural infarction
c.) subendocardial infarction
d.) transmural septal infarction
e.) large combined front wall and posteriorior wall infarction ( circumferential infarction )
E
225.)
in case of hypercholesteremia a heart attack below age 40 comes only rarely
a.) ture
b.) false
false
226.) what is the cause of yellow demarcation zone surrounding acute myocardial infarctions? a.) granulocytic iinfiltration b.) fatty degeneration c.) accumulation of glycogen d.) accumulation of lipofuchsin
A
- ) which special condition causes hemorrhagic infarction ?
a. ) haemophilia
b. ) coronary intervention performed 12h after onset of MI
c. ) thrombophilia
d. ) shock
B
- ) one of the most common complication of myocardial infarction is arrhythmia
a. ) true
b. ) false
false
- ) can occur on basis of scar formation after myocardial infarction :
a. ) narrowing of ventricles
b. ) right to left shunt
c. ) aneurysm
d. ) stenosis of aorta
C
- ) when is myocardial wall rupture most characteristic after MI ?
a. ) immediately
b. ) after several weeks
c. After 1 week
C (4-7 days)
- ) possible cause of hemopericaerdium
a. ) pericardial rupture
b. ) hemorrhagig infarction in neighbouring area
c. ) influenza
d. ) cardiac vein thrombosis
e. ) rupture of MI
E
- ) what is not a complication of a myocardial infarct
a. ) rupture of free ventricular wall
b. ) rupture of affected wall
c. ) fibrosis pericardium
d. ) papillary rupture
C
233.)
complication of chronic cardiac aneurism
a. mural thrombiosis and embolization
b. left ventricular hypertrophy
c. papillary muscle rupture
d. mitral insufficiency
A
234.) (2good) : possible complication of myocardial infarction associated with myocardial rupture a.) aortic stenosis b.) fibrinous pericarditis c.) left to right shunt d.) mitral insufficiency
C,D
- ) heart defects predispose to endocarditis
a. ) true
b. ) false
true
- ) most common cause of myocarditis in europe?
a. ) viruses
b. ) trichinellosis
c. ) chlamydia
d. ) chagasche diseas (worldwide)
e. ) Ecchiococcus
A
- ) sterile endocarditis is ( 2correct)
a. ) endocarditis lenta
b. ) liebmann sachs endocarditis
c. ) marandtic endocarditis
d. ) endocarditis ulcerate
B,C
238.)
Liebman Sacks endocarditis is caused by bacteria.
true
false
false (sterile endocarditis
nonLbacterial thrombotic endocarditis ( 2correct)
a. also called liebmann sachs endocarditis
b. also called endocarditis marantica
c. associated wth autoimmune process
d. associated with pre8terminal state and bad general condition
A,B
The heart lesion associated with SLE:
a. ) Marantic endocarditis
b. ) Liebman Sacks endocarditis
c. ) Pericarditis ( too !!) d.) Myocarditis
B
- ) in liebamnn sachs endocarditis bacteria are demonstrated in the vegetations
a. ) ture
b. ) false
false (nonLsterile)
- ) endocarditis lueitca ( 2correct)
a. ) associated with aortic degeneration
b. ) associated wth AIDS
c. ) associated wth syphilis
d. ) is an infectious endocarditis
A,C