Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Year 5 Pathology > Past Papers Immuno > Flashcards

Past Papers Immuno Flashcards

1
Q

CD4 deficiency, less IgA and IgG made

Unwell by 3 months

A

Bare lymphocyte syndrome type II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CD40L
X-linked
can’t class switch so no IgA and IgG

A

Hyper IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

low Neut, 6 days every 3 weeks

What is Tx?

A

Cyclic neutropenia

give G-CSF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

X linked tyrosine kinase
BTK gene
No mature B cells, no antibodies, symptoms 3-6 months

A

Bruton’s X-linked hypogammaglobulinaemia

Only B cells (which mature in the bone marrow) are deficient. Ear infections are common as these individuals are susceptible to encapsulated bacterial infections) (or if question had said multiple cells lines affected = Anaplastic Anaemia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

congenital neutropenia

A

Kostmann’s syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Rheumatoid arthritis patient with mycobacterial infections

Cause?

A

Iatrogenic - TNFa antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Recurrent pneumococcal disease and meningitis

A

Complement deficiency - C5-C9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Immune deficiency that has improved with age but not mum is concerned about delayed speaking and language

A

Di George

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Marker of antibody mediated rejection

A

C4d

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Most important to match for rejection

A

HLA: DR>B>A

HLA = cell surface proteins, encoded on Chr6 by MHC. Present Ags to Tc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Preformed Ab activates complement
Thrombosis and necrosis
prevented by cross matching (HLA, ABO)

A

Hyper-acute rejection (mins-hrs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CD4 T cells, type IV reaction-> cellular infiltrate

Treat with T cell suppressors

A

Acute Cellular rejection

Weeks - months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Antibodies attack vessels
Exposure -> proliferation + maturation of B cells -> effector phase - antibodies bind to graft endothelium (->vasculitis)

A

Acute - Ab mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Donor cells attacking host
Days-weeks
Rash, N+V, bloody diarrhoea, abdo pain, jaundice
Prophylaxis: methotrexate/cyclosporine, steroids

A

Graft vs Host disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

scl-70 topoisomerase

A

diffuse systemic scleroderma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

anti-cardiolipin

A

anti phospholipid syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

c-ANCA

A

Wegener’s granulomatosis (epistaxis and haematuria)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

AIRE mutation

A

Autoimmune Polyendocrinopathy Syndrome Type 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Grave’s which type of hypersensitivity?

A

Type II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Serum sickness which type of hypersensitivity?

A

Type III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Atopic Eczema which type of hypersensitivity?

A

Type I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

dry eyes and mouth

A

Sjogrens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

weight loss, anti TTG antibodies, anti endomysial antibodies, steatorrhoea

A

Coeliac

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

CREST

A

Calcinosis, Raynaud’s, Esophageal dysmotility, Sclerodactyly, Telangiectasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

anti ds DNA

A

SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

anti parietal cell > anti intrinsic factor

A

Pernicious anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Pollen/fruit ross-react

A

Oral Allergy Syndrome

Sx in mouth only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Bluish mucosa
Seasonal - allergen desensitisation

Tx?

A

Allergic rhinitis

Nasal corticosteroid or oral antihistamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

C1 esterase inhibitor is Mx for

A 
Hereditary angioedema
(angioedema, abdo pain, ascites, facial/testinal oedema)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Urticaria Mx

- idiopathic, food, drugs, latex, viral, infection, exercise

A

H1 receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Angioedema, SOB, low BP

A

Anaphylaxis

Mx - O2 and fluids, help, IM 500mcg Adr, inhaled bronchodilator, 100mcg Hydrocortisone IV, Cloramphenamine 10mcg IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Main cellular source of histamine

A

Mast cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

How do you measure mast cell degranulation

A

Mast cell tryptase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Chemokine responsible for promoting eosinophil growth

A

IL-5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Engulf debris

A

Macrophage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Secrete Igs, cytokines, present antigens

A

B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Present antigens; migrate to lymph nodes when activated

A

Dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Cytotoxic - MHC I

A

CD8 Tc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

HIV Co-receptor

A

CXCR4/CCR5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

HIV Receptor on cell wall which facilitates entry

41
Q

HIV Antigen for non-neutralising antibodies

42
Q

HIV drug that inhibits an enzyme that breaks down proteins

A

Protease inhibitors

43
Q

Can be used for RA

44
Q

For ank spond (with methotrexate), antiTNFalpha receptor

A

Etarnercept

45
Q

Pooled Ig given for

46
Q

Prophylaxis of allograft rejection

A

Basiliximab (Anti CD25, stops Tc prolif)

Anti-thymocyte globulin (affects Tc)

47
Q

RA Mx
(also for Castleman’s)

Antibody to IL6 receptor
reduces macrophage/T cell/B cell/neutrophil activation

A

Tocilizumab

+ anti TNFa e.g. Etanercept

48
Q

Mx Psoriasis

Antibody to p40 subunit of IL12 and IL23

A

Ustekinumab

49
Q

Osteoporosis Mx

Ab to RANK ligand (stops osteoclast differentiation)

A

Denosumab

+ bisposphonate

50
Q

Mx Wegener’s

Antiproliferative agent - B>T cells affected

A

Cyclophosphamide

51
Q

Chronic granulomatous disease Mx

52
Q

Temporal arteritis with high ESR Mx

A

Prednisolone

53
Q

Anti TNFalpha

Used for loads - psoriasis, crohn’s rheumatoid

A

Infliximab

54
Q

Routine but not given to immunocompromised children

55
Q

Travel vaccine not given to someone with ank spond on TNFalpha inhibitor

A

Yellow Fever

56
Q

12-13 year old girls vaccine

57
Q

Vaccine every 5 years given to splenectomy patient

A

Pneumococcal

58
Q

Targets neuraminidase/haemogglutinin

A

Amantadine - influenza A only, targets M2 channel

Oseltamivir, zanamivir, sialic acid - NA inhibitors

59
Q

Vaccine given as post exposure prophylaxis

60
Q

Structure varies yearly

61
Q

Vaccine that eradicated small pox

62
Q

Hep B type vaccine

A

conjugate vaccine

63
Q

Transplant complications

A 
Lymphoproliferative disease (EBV)
Kaposi's sarcoma
64
Q

Cause progressive multifocal leukoencephalopathy

65
Q

Boy whose father got TB after BCG now currently has mycobacterium infection after BCG

A

IFN gamma receptor deficiency

66
Q

A teenage girl who when she goes cross country running gets an erythematous rash on her legs. It is well controlled by antihistamines

A

cold urticaria

67
Q

Man can eat apple pie. But if he eats fresh apples and pears, he gets inflamed lips

68
Q

Man has an allergic reaction during surgery and who’s lips becomes swollen/oedematous when blowing up balloons as his daughter’s birthday party

A

Type 1 hypersensitivity

69
Q

Bloated after drinking milk but not IgE mediated

A

lactose intolerance (enzyme deficiency rather than IgE mediated)

70
Q

A girl with a sore throat is given penicillin and develops a rash. She is found to have EBV.

A

Drug reaction (serum sickness)

71
Q

Teenager + sore throat
3 causes

cause if rapid antigen testing is negative and monospot/heterophile antibody test positive

cause if monospot/heterophile antibody test negative (therefore not EBV) + Rapid antigen test negative

A

Strep throat
EBV
CMV

RAT -ve/ monospot +ve = EBV

CMV

72
Q

Paviluzimab use

A

monoclonal Ab for RSV

73
Q

HIV immune response:
neutralising AB
Non-neutralising Ab

A

neutralising Ab - anti-gp120

non-neutralising - anti- p24

74
Q

What cell is inhibited by the presence of MHC1 on cells

75
Q

What cell is increased in cases of a parasitic infection

A

eosinophils

76
Q

Woman presents with aches all over, (diffuse swelling), and joint stiffness?

A

Rheumatoid arthritis

77
Q

A patient with well controlled HIV, who is currently on HAART. What would you measure?

A

CD4 via FACS (flow cytometry) viral load

78
Q

A women with known SLE presents with an exacerbation of her SLE/worsening symptoms. What do you measure?

79
Q

Rhesus D negative woman is having a Haematopoietic stem cell transplant (HSCT) and is CMV IgG negative. What is the most important thing to ensure in the transplant?

a. HLA of donor and recipient identical
b. Related to recipient and HLA identical
c. HLA haploidentical
d. CMV IgG negative
e. Donor not Rhesus match

A

CMV IgG negative

80
Q

HIV RNA forms HIV, via which error prone enzyme?

A

Reverse transcriptase

81
Q

Which of these vaccines must not be given to a pregnant woman:

a. MMR
b. Hep B
c. DTP

A

MMR (live vaccine) as is BCG, typhoid

82
Q

5 special drug treatments. Which drug can be used to treat some malignancies and affects T cell activity?

a. Infliximab
b. Pembrolizumab
c. Rituximab

83
Q

Gout man on allupurinol

Which meds would need to be altered to prescribed allopurinol?

A

Azathioprine

84
Q

Man has intermittent + tongue swelling for the past 2 years
unresponsive to anti-histamines
is on aspirin and ACE inhibitor
likely cause?

A

Drug induced reaction - angioedema is commonly associated with ACE-inhibitors and NSAIDs.

85
Q

Cell sits immature in periphery

matures + presents to T cells

A

Dendritic cells

86
Q

cell inhibited by MHC1 on cells

87
Q

Heterophile antibody

A

Infectious mononucleosis

88
Q

Anti-Jo-1

A

Dermatomycositis

89
Q

Anti-Thyroperoxidase/throglobulin AB

A

Hashimoto’s thyroiditis

90
Q

Anti-U1RNP Ab (speckled pattern)

91
Q

p-ANCA

A

Microscopic polyangiitis

Churg-Strauss

92
Q

congenital heart block in infant of mum with SLE

A

Anti-Ro Ab

93
Q

AIRE Mutation

A

– Autoimmune polyendochrinopathy syndrome 1

endocrinopathies: T1DM, addison’s, hypothyroidism

94
Q

cancer

Bruton Tyrosine kinase inhibitor ibrutinib be used in

95
Q

Rhesus D negative woman
having a Haematopoietic stem cell transplant is CMV IgG negative
must ensure that…

A

transplant is CMV IgG negative

96
Q

vomiting, white cell casts in urine

A

pyelonephritis

97
Q

pain, haematuria

A

renal calculus

98
Q

most specific marker for Rheumatoid arthritis

A

Anti-Cyclic Citrullinated Peptide

Year 5 Pathology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions