Past Paper Q's - 2018

Question 1

Immunodeficienecy with common gamma chain problem?

Answer 1

X-linked SCID

Question 2

Swollen joint, negative birefringence and needle shaped. What is the enzyme responsible?

Answer 2

Xanthine Oxidase. Rate limiting step is HGPRT

Question 3

What does JC virus cause?

Answer 3

Progressive Multifocal Leukoencephalopathy

Question 4

Virus reactivation post transplant

Answer 4

EBV

Question 5

Most common cause of viral meningitis

Answer 5

Enteroviruses

Question 6

Most common type of CNS tumours in children

Answer 6

Astrocytoma

Question 7

5 year old, Tetany, widened epiphyses + cupping of metaphysis on X-Ray

Answer 7

Ricketxs

Question 8

What is the minimum amount of time to treat a VTE?

Answer 8

3 months

Question 9

Maximum number of HLA mismatches possible with parents on MHC 1?

Answer 9

3, because you have 2A’s, 2B’s, 2C’s, and you’ll get 3 from each parent

Question 10

Ovarian tumour with hair. No immature cells seen.

Answer 10

Mature teratoma

Question 11

What enzyme to confirm cardiac failure?

Answer 11

BNP

Question 12

Liver enzyme raised in MI

Answer 12

Aspartate amintoransferase

Question 13

Old man fallen, dark urine, no blood. What is causing the dark urine?

Answer 13

Myoglobin - Due to rhabdomyolsis

Question 14

Lady with Multiple myeloma and restrictive cardiomyopathy. What will you see on heart biopsy?

Answer 14

Amyloid depositions

Question 15

Man with macrocytic anaemia, atrophy of body of stomach. What substance are they deficient in that leads to B12 malabsorption?

Answer 15

Intrinsic factor

Question 16

Someone with aphthous ulcers, conjunctivitis, diarrhoea & abdo pain

Answer 16

Crohns

Question 17

Lady who went to ?Mexico and ate unpasteurized dairy. 4 weeks later unwell (no diarrhoea mentioned?) Which gram -ve rod caused this?

Answer 17

Brucellosis - Gram -ve rod

Question 18

Non-Tuberculous mycobacterium , some cut on his hand in a man who cleaned a fish tank?

Answer 18

M. marinum

Question 19

Painless penile ulcer which healed in few weeks, followed by fine snail track oral ulcer. Causative organism

Answer 19

Treponema Pallidum

Question 20

Which type of cell does Rituximab target?

Answer 20

Mature B cell

Question 21

What is the usual prophylaxis for allograft rejection ?

Answer 21

Mycophenolate mofetil, pred, tacrolimus

Question 22

Which allergy is more likely to present in child than adult?

Answer 22

Egg

Question 23

How does melanoma spread? Haematological or lymph nodes?

Answer 23

Haem

Question 24

Anti-Tnf-A/Jakinibs and anti-IL/AntiTNFfA - What treats RA and What treats psoriasis?

Answer 24

Anti-tnf-A for RA

Anti IL for psoriasis

Question 25

Which antibody gives innate immunity to HIV?

Answer 25

GP41 and GP120

Question 26

What genetic defect gives immunity to HIV?

Answer 26

CCr5 receptor immunity