Past Paper Q's - 2017 Flashcards

1
Q

A man after a road traffic accident (Man vs Car) requires a 6 unit transfusion, and then becomes acutely breathless/SOB, with a fever and tachycardia

A

Transfusion related lung injury (TRALI)
(Constellation of Tachycardia, Hypotension, and Fever + Shortness of breath +/or low O2 sats or Bilateral lung infiltrates)

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2
Q

Which deficiency more common in coeliac?

A

Folate

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3
Q

A girl with a sore throat develops rash after penicillin

A

Means EBV/CMV - Counts as drug reaction, not penicillin allergy

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4
Q
  1. An overweight individual with diabetes has longstanding bone/back pain. They are found to have paraprotein IgA ~8g/dl, and GFR 55mls/min/1.73m^2. FBC normal and albumin normal.
A

MGUS - Even though they have CRAB symptoms. You must rule out other causes of symptom. Weight causers back pain, diabetes causes renal damage

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5
Q

What is the most common cause of traveller’s diarrhoea?

A

Escherichia Coli

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6
Q

Microbiology - Food poisoning question – guy develops foul-smelling diarrhoea and cramping pain 5 days after eating chicken at a barbeque

A

Campylobacter

1-6 hrs: Staphylococcus aureus, Bacillus cereus*
12-48 hrs: Salmonella, Escherichia coli (watery camper)
48-72 hrs: Shigella (bloody), Campylobacter (hayfever campylo (flu prodrome) + (diarrhoea can be bloody))
7 days: Amoebiasis (Bloody), Giardiasis (Non-bloody diarrhoea)

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7
Q

Diarrhoea spreading on the ward

A

Norovirus

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8
Q

Which/what cell is inhibited by the presence of MHC1 on cells?

A

NK Cells

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9
Q

Pernicious anaemia stomach findings

A
  • Weakened stomach lining (atrophic gastritis)

- An autoimmune condition in which the body’s immune system attacks intrinsic factors or the cells that make it.

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10
Q

Most common type of malignancy in the breast?

A

Invasive ductal carcinoma (accounts for 75% of all breast cancer) > DCIS is the most common type of non-invasive breast cancer.

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11
Q

Which/What cancer is also known as non-specific type?

A

Invasive ductal carcinoma - No special findings on histology

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12
Q

Which/What cancer is associated with (? the presence of?) E cadherins?

A

If it said E-cadherin present, answer = Invasive ductal carcinoma.
However, if it said E-Cadherin negative, answer = Invasive lobular carcinoma

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13
Q

Cancer which has a high, medium and low stage to it.

A

DCIS

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14
Q

Fibro-epithelial tumour with abundant stromal elements.

A

Phyllodes tumour

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15
Q

Which/What enzyme if low, leads to hyperuricemia/rise in blood uric acid?

A

HGPRT

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16
Q

Which/What enzyme regulates the rate limiting step in haem biosynthesis pathway/of the blood?

A

ALA Synthase (d-Aminolevulinate Synthase) (because it is concerned with the SYNTHESIS of new haemoglobin)

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17
Q

Which enzyme is raised in mumps. Which enzyme raised in pancreatitis?

A

Amylase-S (Serum amylase is often elevated with any inflammation of the salivary glands. In Pancreatitis Amylase-P is often raised).

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18
Q

Man with weakness in the gym and ptosis.

A

M Gravis

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19
Q

A 12 year old boy has recurrent chest infections, and has an ear infection. He doesn’t have any B Cells.

A

Brutons - Which is solely a B cell deficiency

20
Q

Boy with abscesses has a positive NBT.

A

Positive NBT means Myeloperoxidase deficiency. Negative means GCD

21
Q

A man presents with the symptoms of a UTI and acute onset costovertebral pain. He is found to have pus cells and blood in his urine. What is the most likely cause?

A

Acute pylonephritis - Infection causes the pus

22
Q

A man with AF (Atrial fibrillation) develops fever, nausea, vomiting and pain in his right loin/flank. What is the most likely cause?

A

Renal Infarct

23
Q

Most common causes of DIC in pregnancy

A

Abruption, followed by Amniotic Fluid Embolism

24
Q

MAHA + Thrombocytopaenia + Abnormal PT/APTT

A

DIC

25
Q

Which drug do you give to a woman who is infected with herpes zoster in pregnancy?

A

Aciclovir

26
Q

Man, ex-smoker, with history of hypertension and MI, has sudden chest pain which radiates to the neck

A

Descending Internal coronary artery thrombus

27
Q

Man has an MI 3 years ago. Now comes into hospital feeling very unwell. Is having a sample taken from their pericardial layer and you find blood is aspirated from the pericardium

A

Ventricular Rupture or Tamponade

28
Q

Causes of Meningitis in baby in <3 vs Over 3 months

A

<3: Listeria, E. Coli, GBS
>3: Neisseria Meningitidis, Pneumococcus HiB (Think unvaccinated)
Over 6 years old: Meningococcus or Pneumococcus

29
Q

Coag +ve Staph vs Coag -ve Staph

A

+ve Aureus

-ve Epidermis

30
Q

Optoochin +ve vs Optochin -ve Strep

A

+ve - Pneumoniae

-ve - Viridans

31
Q

Ibrutinib treats what cancer

A

CLL

32
Q

Most important matching to do before transplants?

A

CMV - As it can kill

HLA will just lead to rejection

33
Q

Which type of T cell controls cell mediated rejection of host?

A

CD4

34
Q

Which drug can’t you take Allupurinol with?

A

Azothioprine

35
Q

Common causes of drug induced angiodema?

A

ACEi or Aspirin

36
Q

Most common type of bladder cancer?

A

Transitional cell

37
Q

What type of bilirubin causes itching?

A

Conjugated

38
Q

Most common type of ovarian benign tumour

A

Serous Cystadenoma

39
Q

The walls of vessels express anti-thrombotic factors. Why is this?

A

Thrombomodulin

40
Q

What vector transmits leishmaniasis, and which one transmits Trypanosoma brucei rhodesiense?

A

Tetse - Trypan

Sandlfly - Leishman

41
Q

Draw the grid for PPV, Sensitivity, Specificity, and NPV

A

https://www.med.uottawa.ca/sim/data/Images/Sen_spec.gif

42
Q

Which of these can cause peri/neonatal illness without causing damage to the foetus if the mother is infected antenatal?

A

Enterovirus

43
Q

Most common HAP

A

Staph Aureus

44
Q

Medullary Thyroid Cancer marker

A

Calcitonin (Carcinoembryonic Antigen less sensitive)

45
Q

Drug used to treat Severe malaria falciparum and Moderate

A

Severe - Artensunate

Moderate - Qunine + doxy, or Malarone, or ACT

46
Q
  1. A patient required an aortic valve replaced 3 months ago. They have now come back a few weeks later with jaundice, Hb-urea (haemoglobinuria), and raised reticulocytes. What is the cause?
A

Mechanical Haemolytic anaemia

47
Q

External carotid Vasculitis

A

Giant cell arteritis