passmed

Question 1

in a man HNPCC associated with what other cancer

Answer 1

pancreatic

Question 2

difference bwteen fap and HNPCC

Answer 2

FAP causes thousands of polyps to develop in the colon, while HNPCC causes few or none

HNPCC (Lynch syndrome), an autosomal dominant condition, is the most common form of inherited colon cancer. - MLH1 MSH2

FAP is a rare autosomal dominant condition which leads to the formation of hundreds of polyps by the age of 30-40 years. Patients inevitably develop carcinoma. It is due to a mutation in a tumour suppressor gene called adenomatous polyposis coli gene (APC), located on chromosome 5. - die earlier

Question 3

FAP can lead to what other syndrome and other tumours where

Answer 3

Patients with FAP are also at risk from duodenal tumours. A variant of FAP called Gardner’s syndrome can also feature osteomas of the skull and mandible, retinal pigmentation, thyroid carcinoma and epidermoid cysts on the skin