PASSMED Flashcards
Main role if IL1
Induce fever
What cytokine is responsible for hypotension
IL1-
main immunoglobin in breast milk
Iga
effects of il1
- increase expression of adhesion on endothelium
- release of NO
- vasodilator
what IG provides localised protection on mucous membranes
Iga
ACID- EGG-T
Type 1 Anaphylactic
Type 2 Cytotoxic
Type 3 Immune complex
Type 4 Delayed type
IgE
IgG
IgG
T cells
First immunoglobulin secreted in response to infection
Igm
IL-2 is mainly secreted by……..
Th1 cells
Which cell surface marker quantifies total T cell count?
CD3
What part of immunoglobulin is responsible for antigen affinity
Variable region
Receptor for Epstein Barr virus
Cd21
What cell mediated organ rejection
B cells
Immunological changes seen in HIV
Reduction in CD4, IL2, NK function, hypersensitivity response
Increase in b cell activation, b2 microglobulin
In the context of T cell development, what is the purpose of negative selection?
To eliminate T cells that react strongly with self-antigens
What is the primary target of the autoantibodies involved in the pathophysiology of myasthenia gravis?
Postsynaptic acetylcholine receptors
Pernicious anaemia is an autoimmune condition caused by ….
Autoantibodies against gastric parietal cells and or / intrinsic factor
Which of the following describes the function of T-helper 2 (Th2) cells?
Encourage B-cell antibody production
Role of il3g
Stimulates differentiation and proliferation of b cells
Role of IL5
Stimulate production of eosinophils
what immunoglobulin activates b cells
Igd
what ig leads to mast cell degranulation
ige
mechanism of anakinra
IL1 receptor antagonist
helper t cells reocognise antigens presented by..
MHC CLASS 2
what IL induce fever
1L1 and IL6
CHEMOTAXIS of neutrophils is what IL
il8
What do th2 producee
IL 4,5,6,10
macrophages produce what cytokine
IL1,6,
What does IL10 DO
inhibit th1 cytokine production
role of IL4
proliferation of b cells
what Ig provides immunity to helminths and worms
Ige
