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immunology > PASSMED > Flashcards

PASSMED Flashcards

1
Q

Main role if IL1

A

Induce fever

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2
Q

What cytokine is responsible for hypotension

A

IL1-

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3
Q

main immunoglobin in breast milk

A

Iga

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4
Q

effects of il1

A
  • increase expression of adhesion on endothelium
  • release of NO
  • vasodilator
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5
Q

what IG provides localised protection on mucous membranes

A

Iga

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6
Q

ACID- EGG-T

A

Type 1 Anaphylactic
Type 2 Cytotoxic
Type 3 Immune complex
Type 4 Delayed type

IgE
IgG
IgG
T cells

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7
Q

First immunoglobulin secreted in response to infection

A

Igm

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8
Q

IL-2 is mainly secreted by……..

A

Th1 cells

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9
Q

Which cell surface marker quantifies total T cell count?

A

CD3

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10
Q

What part of immunoglobulin is responsible for antigen affinity

A

Variable region

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11
Q

Receptor for Epstein Barr virus

A

Cd21

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12
Q

What cell mediated organ rejection

A

B cells

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13
Q

Immunological changes seen in HIV

A

Reduction in CD4, IL2, NK function, hypersensitivity response
Increase in b cell activation, b2 microglobulin

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14
Q

In the context of T cell development, what is the purpose of negative selection?

A

To eliminate T cells that react strongly with self-antigens

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15
Q

What is the primary target of the autoantibodies involved in the pathophysiology of myasthenia gravis?

A

Postsynaptic acetylcholine receptors

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16
Q

Pernicious anaemia is an autoimmune condition caused by ….

A

Autoantibodies against gastric parietal cells and or / intrinsic factor

17
Q

Which of the following describes the function of T-helper 2 (Th2) cells?

A

Encourage B-cell antibody production

18
Q

Role of il3g

A

Stimulates differentiation and proliferation of b cells

19
Q

Role of IL5

A

Stimulate production of eosinophils

20
Q

what immunoglobulin activates b cells

A

Igd

21
Q

what ig leads to mast cell degranulation

A

ige

22
Q

mechanism of anakinra

A

IL1 receptor antagonist

23
Q

helper t cells reocognise antigens presented by..

A

MHC CLASS 2

24
Q

what IL induce fever

A

1L1 and IL6

25
Q

CHEMOTAXIS of neutrophils is what IL

A

il8

26
Q

What do th2 producee

A

IL 4,5,6,10

27
Q

macrophages produce what cytokine

A

IL1,6,

28
Q

What does IL10 DO

A

inhibit th1 cytokine production

29
Q

role of IL4

A

proliferation of b cells

30
Q

what Ig provides immunity to helminths and worms

A

Ige

immunology (5 decks)

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