Passive Immunity Flashcards
passive immunity
transfer of PRE-formed immune components from 1 individual to another
Passive immunity time farm of effectiveness
effective immediately for antibody function, does not take several weeks/months like active immunization
Passive immunity in treating toxins
non-immunized patient with high levels of toxins (tetanus, diphtheria, snake or scorpion venom) can respond immediately
When would you use passive immunity?
high levels of toxins in non-immunized patient, exposure to infected individual, suppression of immune response
Serum therapy
giving serum of a recovered patient (measles) to a child who had been exposed but had not yet developed the disease, prevented the disease formation
Immunoglobulin
describes the fraction of serum protein gamma globulins that possess antibody reactivity
Polyclonal antibodies are derived from
a host that had been immunized or recovered from an infection
How would one concentrate the antibodies?
precipitate gamma globulin fraction using EtOH and ammonium sulfate, lyophilize and reconstitute
Human Immune Globulin (HISG)
gamma globulin fraction concentrate, stable and rapid Ab levels in blood, administered IM or IV.
HISG used for
Hep A (pre- and post- exposure), Measles (post-), Hypogammaglobulinemia, IGIV for immunocompromised
Placental immune serum globulin
enriched source of Ig
Specific Human Immune Globulin (SHIG)
Donors have specific antibodies due to previous infection or immunization
SHIG - Rho (D) Immune Globulin (RhoGAM)
prevention of erythroblastosis fetalis
SHIG - Varicella-zoster immune serum globulin (VZIG)
immunosuppressed individuals and non-immune pregnant females and infants following exposure
SHIG - Hepatits B (HBIG)
following exposure