parvovirus

Question 1

how is parvovirus PVB19 transmitted

Answer 1

resp droplets

Question 2

what percentage of women are already immune to PVB19

Answer 2

50% leaving 50% susceptible to infection

Question 3

risk factors for contracting PVB19

Answer 3

being a schoolteacher or working with children

Question 4

manifestations of PVB19 in adults

Answer 4

flu-like illness and arthropathy (joint pains)

Question 5

manifestation of PVB19 in children

Answer 5

slap cheek

Question 6

transmission rate from placenta to fetus?

Answer 6

17-33% especially higher risk of transmission in second trimester

Question 7

Consequences of congenital infection

Answer 7

spontaneous remission
OR aplastic anaemia leading to:
hydropic fetus from high output cardiac failure and liver congestion seen on USS

Question 8

Signs of hydrops fetus

Answer 8

high velocity of blood flow in middle cerebral artery of fetus but this can have other causes aside from PVB19

Question 9

How do you diagnose PVB19 infection

Answer 9

IgM to PVB19 in mother, compared to a booking sample showing no antibodies
PCR in maternal or fetal blood or amniotic fluid is very accurate

Question 10

How do you treat hydrops ferus

Answer 10

in utero transfusion or spontaneous recovery

Question 11

what is the risk of fetal death with PVB19

Answer 11

<20/40 = 10% risk of death as cannot give intrauterine transfusion
>20/40 = 1% risk as given in utero transfusion and no long term damage