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Viro test 2 > Parvoviridae > Flashcards

Parvoviridae Flashcards

1
Q

Enveloped or Nonenveloped?

A

Nonenveloped

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2
Q

Virion capsid has ____ protein subunits with a T number of ___

A

60, 1

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3
Q

DNA of parvoviridae

A

single stranded, linear

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4
Q

Disinfection is difficult because

A

resists 60C for 60 min and PH 3-9

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5
Q

Replication occurs

A

in the nucleus

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6
Q

infection leads to

A

large intranuclear inclusion bodies

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7
Q

Subfamily that infects insects

A

Densovirinae

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8
Q

Subfamily that infects vertebrates

A

Parvovirinae

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9
Q

Genera of parvovirnae

A 
Parvovirus
Erythovirus 
Bocavirus
Dependovirus
Amdovirus
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10
Q

Parvovirus replication

A

Only in cells that pass through the mitotic S phase

actively dividing cells

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11
Q

Erythrovirus

A

“fifth disease, slap cheek rash”
replicate autonomously
Humans (parvovirus B19)- rash, anemia, arthritis

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12
Q

Dependovirus

A

do not cause disease
unable to replicate without helper viruses (usually adenovirus)
goose and duck parvovirus
sometimes bovine parvovirus 2

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13
Q

Bocavirus

A

Contain a 3rd Open Reading Frame
infect GI and respiratory
Humans, dogs, cattle

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14
Q

Feline parvovirus (panleukopenia) general

A

Feline distemper
Feline infectious enteritis
Highly contagious, often fatal

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15
Q

FPV epidemiology

A

Ubiquitous in environment
unvaccinated kittens are protected until 3 mon.
can be subclinical
shed in urine and feces for 6 weeks after recovery

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16
Q

FPV transmission

A

Infected oro-nasally
In-utero transmission
mechanical transmission by flies

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17
Q

FPV pathogenesis

A

enter oropharynx, replicate in pharyngeal lymphoid tissue
viremia
other organs from blood

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18
Q

Hallmark of FPV

A

severe leukopenia
affects WBC in circulation and lymphoid organs (become destroyed)
thrombocytopenia due to bone marrow damage

19
Q

FPV damage to GI

A

crypts cells not absorptive cells

blunt villi, diarrhea

20
Q

In Utero FPV

A

death, abortion, mummified fetuses

near end of gestation- live kittens with neural tissue damage, variable effects

21
Q

FPV CNS

A

optic nerve and retina damage

cerebellar hypoplasia if cats are infected 2 weeks before or after birth

22
Q

FPV DIC

A

Kittens get secondary bacT infection –> gram negative LPS is released –> causes coagulation factors to go into overdrive —> DIC –> hemorrhage

23
Q

FPV clinical signs

A 
diarrhea
lymphopenia
neutropenia
anemia
abortion 
cerebellar ataxia
depression
rough coat
vomiting
sever dehydration
24
Q

Incubation of FPV

A

2-10 days

25
Q

FPV is most common in

A

kittens 3-5 months

26
Q

FPV diagnosis

A

leukopenia and neutropenia is more consistent than lymphopenia

27
Q

Vaccine for FPV

A

Attenuated live vaccines (MLV)

do not give to pregnant, immunosuppressed, or kittens less than 4 weeks old

28
Q

Canine Parvovirus (CPV)

A

Type 1= not important

Type 2 = very common with a, b, and c antigenic variants

29
Q

Distribution of CPV-2

A

North America= CPV2b and CPV2c

30
Q

CPV2 epidemiology

A

highly contagious
stable in environment
resistant to disinfectants
can be indoors for 2 months

31
Q

CPV2 transmission

A

oro-nasal exposure to contaminated feces
In- utero
contact with contaminated fomites

32
Q

CPV2 pathogenesis

A 
enteritis
myocarditis 
panleukopenia 
CNS
cutaneous disease
33
Q

Age related symptoms of CPV2

A

2-12 days : general neonatal, uncommon
3-8 weeks: myocarditis
2-4 months: enteritis and panleukopenia, most common

34
Q

CPV2 myocarditis

A

necrosis with acute cardiopulmonary failure

sudden death

35
Q

Diagnosis of CPV2

A

snap test

everything except serology because the dog might already be vaccinated

36
Q

Vaccine schedule CPV2

A

6-8 weeks, 10-12 weeks, 14-16 weeks, booster at 1 yr, then every 3 years

37
Q

Vaccines for CPV2

A

pregnant dogs or colostrum derived puppies- inactivated

all others- modified live

38
Q

Porcine Parvovirus (PPV)

A

causes reproductive failure

SMEDI (stillbirth, mummification, embryonic death, infertility)

39
Q

Transmission of PPV

A

oronasal in the non-immune pregnant sow
transplacental transmission
venereal from boar semen

40
Q

PPV Pathogenesis

A

takes 15 days to reach fetuses
each fetus has its own placenta, so death at different stages is seen
extensive endothelial cell damage

41
Q

PPV Clinical signs

A

mummified fetuses rather than abortion
before 30 days - fetus reabsorbed
30-70 days - fetus becomes mummified
after 70 days- lesions but survive

42
Q

Diagnosis of PPV

A

FA staining for frozen fetal tissue
PCR
ELISA
Not serology

43
Q

PPV is non/persistent and does/does not have periodic shedding

A

persistent with periodic shedding

44
Q

Vaccination schedule

A

vaccinate 2x, 2 weeks apart, several weeks before breeding

Viro test 2 (3 decks)

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