Papillomaviridae

Question 1

Papillomaviridae general properties

Answer 1

non enveloped
spherical
single molecule of circular double stranded DNA
resistant virus, survives detergents, low pH and high temps

Question 2

Papillomaviridae produce

Answer 2

warts on the skin and mucous membranes

Question 3

Warts are

Answer 3

benign neoplasms that can regress spontaneously

can sometimes progress to malignancy

Question 4

human example of papillomaviridae

Answer 4

HPV causing cervical cancer in women

Question 5

Replication occurs in

Answer 5

stratified squamous epithelium

Question 6

Papilomaviruses infect

Answer 6

keratinocytes in the basal layer of the epithelium that becomes exposed through micro-wounds

Question 7

viral genomes are established as

Answer 7

low copy episomes

Question 8

Virus accumulation and cytopathology is most noticeable in

Answer 8

the stratum granulosum

Question 9

virions are shed from

Answer 9

the uppermost layers of the epithelium

Question 10

In which form of warts is the DNA episomal?

Answer 10

Benign

Question 11

Bovine papillomatosis host

Answer 11

cattle

seen in cattle more than any other domestic animal

Question 12

Bovine papillomatosis transmission

Answer 12

contaminated fomites

venereal

Question 13

Fibropapilloma

Answer 13

caused by bovine papillomavirus types 1, 2 and 5

Question 14

fibropapilloma description

Answer 14

fibrous core covered to a variable depth with statified squamous epithelium, the outer layers of which are hyperkeratinized
cauliflower growths
gray to black in color
rough and spiny to the touch

Question 15

fibropapilloma locations

Answer 15

udder and teats
head, neck and shoulders
omasum, vagina, vulva, penis, anus

Question 16

fibropapilloma in young bulls

Answer 16

can cover the tip of the penis and make the bull of no value as stud bulls

Question 17

cutaneous papillomas

Answer 17

bovine papillomavirus type 3
lack a fibrous core
flat with a broad base
lesions tend to persist

Question 18

Braken Fern and bovine papillomaviruses

Answer 18

ingestion can cause a transition to invasive carcinoma of the alimentary tract
enzootic hematuria

Question 19

Bovine papillomavirus treatment

Answer 19

surgical excision or cryosurgery with liquid nitrogen
podophyllim or undiluted DMSO
bovine interferon alpha

Question 20

Canine Oral Papillomatosis

Answer 20

self limiting disease
warts on lips, spreading to the buccal mucosa, tongue, palate and pharynx
regresses spontaneously
can also be located ocularly

Question 21

Canine oral papillomatosis is characterized histologically by

Answer 21

epithelial hyperplasia and cytoplasmic vacuolization (koilocytosis)

Question 22

clinical signs of canine oral papillomatosis

Answer 22

halitosis
hemorrhage
hypersalivation (ptyalism)
discomfort

Question 23

autogenous vaccines

Answer 23

can be tried for canine oral papillomatosis
wart is removed, made into a vaccine and reinjected
efficacy doubtful

Question 24

Equine sarcoids

Answer 24

bovine papillomavirus 1 or 2
most common neoplasms in horses
locally invasive benign fibroblastic skin tumors

Question 25

Treatment of equine sarcoids

Answer 25

``` can be surgically removed by will recur persist for life cryotherapy local immune modulation local radiotherapy ```

Question 26

transmission of equine sarcoids

Answer 26

fomites?

Question 27

sarcoids are common

Answer 27

in traumatized areas

Question 28

sacroids can look similar to

Answer 28

proud flesh