Particle Size Analysis Flashcards

1
Q

Challenges

A
  • HETEROGENEOUS powder particle size - RANGE
  • IRREGULAR particle shapes
  • 2D
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2
Q

Solutions

A

Equivalent sphere diameter
Statistics
Analytical techniques

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3
Q

Particle shape considers

A

Convexity, aspect ratio, circularity, solidity

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4
Q

Particle size ANALYTICAL TECHNIQUES

A
Sieving
sedimentation
microscopy
image analysis
laser diffraction
dynamic light scattering
electrozone sensing
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5
Q

LASER DIFFRACTION:

particle size range

A

0.01-3500ym

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6
Q

LASER DIFFRACTION:

mechanism

A

Particles passing through the laser beam scatter light.

ANGLE OF LIGHT SCATTER is measured by photodetectors around sample chamber
- measures LIGHT INTENSITY

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7
Q

LASER DIFFRACTION:

smaller particles have a ____ scatter angle

A

WIDER

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8
Q

LASER DIFFRACTION:

advantages

A

RAPID (mins)
minimal sample prep
NO CALIBRATION

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9
Q

DYNAMIC LIGHT SCATTERING:

particle size range

A

0.3nm-10ym

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10
Q

DYNAMIC LIGHT SCATTERING:

mechanism

A

(same as laser diffraction)
BUT
Photodetectors measure FLUCTUATIONS in scatter.

Scatter due to BROWNIAN MOTION

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11
Q

Compare LD & DL:

A

LD uses wet & dry samples (DL: wet only)
LD: broader particle size range
LD measures ANGLE OF LIGHT SCATTER
DL measures FLUCTUATIONS of light scatter

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12
Q

NORMAL DISTRIBUTION CURVE:
mean
median
mode

A

mean=median=mode

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13
Q

NORMAL DISTRIBUTION CURVE:

shows

A

UNIFORMITY of particle size

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14
Q

BIMODAL DISTRIBUTION:

relate modes & peaks

A

1 peak = 1 mode

2 peaks = 2 modes

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15
Q

BIMODAL DISTRIBUTION:

shows

A

2 or more distinct populations in powder

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16
Q

NEGATIVE SKEW:
mean
median
mode

17
Q

NEGATIVE SKEW:

shows

A

MORE LARGER PARTICLES

18
Q

NEGATIVE SKEW:

peak lies on ___ side

19
Q

POSITIVE SKEW:
mean
median
mode

A

mean>median>mode

20
Q

POSITIVE SKEW:

shows

A

MORE SMALLER particles

21
Q

POSITIVE SKEW:

peak lies to ____ side

A

LEFT

closest to y axis

22
Q

D values:

calculate

23
Q

SPAN

equation

A

(D90-D10)/D50

24
Q

SPAN shows

A

width of particle size distribution

25
IQCS<0
NEGATIVE SKEW
26
IQCS>0
POSITIVE SKEW
27
IQCS=0
NORMAL DISTRIBUTION
28
IQCS values lie between range .......
-1 and +!
29
IQCS shows
Interquartile coefficient of skewness
30
POLYDISPERSITY INDEX: shows
uniformity of particle size
31
POLYDISPERSITY INDEX: | assumes
NORMAL DISTRIBUTION
32
POLYDISPERSITY INDEX: | equation
SD | mean particle size
33
POLYDISPERSITY INDEX: | MONODISPERSE
narrow dist, uniform particle size
34
POLYDISPERSITY INDEX: | POLYDISPERSE
broad dist | variable particle size
35
DYNAMIC LIGHT SCATTERING: | which equation relates?
Stokes-Einstein Equation