Allergies Flashcards
Hypersensitivity
an inappropriate immune response leading to tissue damage and other symptoms
Type I Hypersensitivity reactions mediated by -
IgE
Type II & III Hypersensitivity reactions mediated by -
IgG
Type IV Type I Hypersensitivity reactions mediated by -
T cells
Hygiene Hypothesis
More exposure to pathogens → immunity
Genetic susceptibility
Polymorphisms in IL4 & HLA
Type I-III are _____ mediated
ANTIBODY
ANAPHYLAXIS
systemic reaction in response to an allergen introduced directly into the bloodstream
outline a T1 hypersensitivity reaction
Pre-phase SENSITISATION
Allergen inhaled
Dendritic cells process & antigen presentation in lymph nodes
IgE binds FcR on mast cells & basophils
Subsequent exposure to antigen cross-links IgE - mast cell degranulation - INFLAMAMTION
MAST CELL becomes a loaded gun
Clinical effects of mast cell degranulation
Food allergies
allergic rhinitis
bronchial asthma
anaphylaxis
Preformed type I mediators
HISTAMINE
heparin
TNFa