Allergies Flashcards

1
Q

Hypersensitivity

A

an inappropriate immune response leading to tissue damage and other symptoms

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2
Q

Type I Hypersensitivity reactions mediated by -

A

IgE

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3
Q

Type II & III Hypersensitivity reactions mediated by -

A

IgG

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4
Q

Type IV Type I Hypersensitivity reactions mediated by -

A

T cells

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5
Q

Hygiene Hypothesis

A

More exposure to pathogens → immunity

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6
Q

Genetic susceptibility

A

Polymorphisms in IL4 & HLA

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7
Q

Type I-III are _____ mediated

A

ANTIBODY

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8
Q

ANAPHYLAXIS

A

systemic reaction in response to an allergen introduced directly into the bloodstream

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9
Q

outline a T1 hypersensitivity reaction

A

Pre-phase SENSITISATION
Allergen inhaled
Dendritic cells process & antigen presentation in lymph nodes
IgE binds FcR on mast cells & basophils
Subsequent exposure to antigen cross-links IgE - mast cell degranulation - INFLAMAMTION

MAST CELL becomes a loaded gun

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10
Q

Clinical effects of mast cell degranulation

A

Food allergies
allergic rhinitis
bronchial asthma
anaphylaxis

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11
Q

Preformed type I mediators

A

HISTAMINE
heparin
TNFa

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