Inhaled RoA

Question 1

Outline DPI & delivery to lungs

Answer 1

• Dry powder blend
• IFR - breath actuated AEROSOLISATION
• Turbulent airflow generated
• SEPARATION of DRUG from carriers in formulation
• Small drug particles deposited in LRT - dissolution & absorption
• Larger carriers deposited in pharynx by inertial impaction

Question 2

DPI inhalation

Answer 2

DEEP, SHARP BREATH

Question 3

pMDI inhalation

Answer 3

SLOW, STEADY BREATH

Question 4

Drug particle size for DPIs

Answer 4

2-5ym

Question 5

MICROIONISED powder problems

Answer 5

Poor flow properties
poor flowability
ROUGH SURFACES
Non-homogeneous

Question 6

MICRONIZATION

• function
• advantages
• process

Answer 6

• reduce drug/carrier particle size - ym
• HOMOGENEITY & control particle size
• jet milling

Question 7

Commonest carrier particle:

Answer 7

LACTOSE

Question 8

Why are carriers incorporated?

Answer 8

Overcome cohesive forces between micronised particles
> drug/carrier blend
> IMPROVED powder flow

Question 9

Effects of a ROUGH CARRIER surface

Answer 9

Holds micronised drug too strong during storage
> cannot separated when inhaled
> drug deposition at back of throat

Question 10

Effects of a smooth carrier

Answer 10

WEAK drug-carrier interactions
> DISPERSION during inhalation
Difficulty during manufacture

Question 11

2 common multi-dose DPIs

Answer 11

Accuhaler

Turbohaler

Question 12

SABA drugs

Answer 12

SHORT ACTING B2 AGONIST

Salbutamol
terbutaline

Question 13

LABA drugs

Answer 13

LONG ACTING B2 AGONIST

Salmeterol
Formoterol

Question 14

LAMA drug

Answer 14

LONG ACTING M ANTAGONISTS

Titropium

Question 15

ICS drugs

Answer 15

Budesonide
Beclometasone
Fluticasone

Question 16

Counselling point when patient uses an ICS inhaler

Answer 16

Rinse mouth after inhalation of ICS