Partial 2 - Inflammation and immunology

Question 1

Which antibody is produced in Type I Hypersensitivity

Answer 1

IgE

Question 2

Prototypical disorders of Type I Hypersensitivity

Answer 2

Anaphylaxis; allergies; bronchial asthma (atopic forms)

Question 3

What is the name of Type II Hypersensitivity

Answer 3

Antibody-mediated hypersensitivity

Question 4

Which antibody is produced in Type II Hypersensitivity

Answer 4

IgG and IgM

Question 5

Prototypical disorders of Type II Hypersensitivity

Answer 5

Autoimmune hemolytic anemia
Goodpasture syndrome
Myasthenia Gravis 
Graves disease
Pernicious anemia

Question 6

What is the name of Type III Hypersensitivity

Answer 6

Immune complex-mediated hypersensitivity

Question 7

Prototypical disorders of Type III Hypersensitivity

Answer 7

SLE
Rheumatoid arthritis
Some forms of glomerulonephritis
Serum sickness
Arthus reaction
Polyarteritis nodosa

Question 8

What is the name of Type IV Hypersensitivity

Answer 8

Cell-mediated hypersensitivity

Question 9

Prototypical disorders of Type IV Hypersensitivity

Answer 9

Contact dermatitis
Multiple Sclerosis
Type I Diabetes
Tuberculosis

Question 10

SLE autoantibodies

Answer 10

ANA
Anti-dsDNA (double-stranded DNA)
Anti-Sm (ribonuclear core protein, Sm antigen)
Anti-RNP UI (ribonuclear protein)
Anti-SS-A (Ro)
Anti-SS-B (La)
Anti-histones
Antiphospholipid

Question 11

Sjøgren syndrome autoantibodies

Answer 11

Anti-SS-A (Ro)

Anti-SS-B (La)

Question 12

Systemic sclerosis autoantibodies

Answer 12

Anti-Scl-70 (DNA topoisomerase I)

Anti-centromere

Question 13

Disorder with Anti-mitochondrial autoantibodies

Answer 13

Primary biliary cirrhosis

Question 14

SLE symptoms

Answer 14

Photosensitivity, rash, ulcers of mouth and nose, pleuritis, pericarditis, arthritis, nephritis, anemia, thrombocytopenia, leukopenia

Question 15

Cardinal signs of inflammation

Answer 15

Pain (Dolor)
Redness (Rubor)
Hot (Calor)
Swelling (Tumor)
Loss of function

Question 16

Rheumathoid arthritis symptoms

Answer 16

Sunrise stiffness, soft feeling in joints, swelling in joints, synovitis, systemic involvement (fever, anemia, vasculitis), pulmonary fibrosis,

Question 17

Which disease causes pannus formation

Answer 17

Rheumatoid arthritis

Question 18

Which disease increases the risk of lymphoma?

Answer 18

Sjøgrens syndrome

Question 19

Rheumatoid arthritis autoantibodies

Answer 19

Rheumatoid factor (IgM against Fc portion of IgG)
Anti-citrillinated
RANA

Question 20

Sjøgrens syndrome symptoms

Answer 20

Xeropthalmia, xerstomia, keratoconjuctivitis, dryness in general

Question 21

Scleroderma is a condition characterized by excessive deposition of what in the skin and multiple internal organs?

Answer 21

Collagen

Question 22

Diffuse cutaneous scleroderma autoantibodies

Answer 22

Anti-Scl-70 (Anti-topoisomerase)

Question 23

Limited cutaneous scleroderma autoantibodies

Answer 23

Anticentromere

Question 24

Scleroderma symptoms

Answer 24

CREST syndrome (Limited)
End organ involvement (Diffuse)

Question 25

Uveitis, iritis and hypopyon is characteristic for which disease?

Answer 25

Behcet disease

Question 26

Mixed connective tissue disease consists of

Answer 26

SLE, Scleroderma, Polymyositis, Rheumatoid arthritis

Question 27

Mixed connective tissue disease autoantibodies

Answer 27

U1-RNP

Question 28

Which disease has c-ANCA autoantibodies

Answer 28

Wegeners Granulomatosis

Question 29

Which disease has p-ANCA autoantibodies

Answer 29

Microscopic poylangitis

Churg-Strauss syndrome