Partial 2 - Inflammation and immunology Flashcards
Which antibody is produced in Type I Hypersensitivity
IgE
Prototypical disorders of Type I Hypersensitivity
Anaphylaxis; allergies; bronchial asthma (atopic forms)
What is the name of Type II Hypersensitivity
Antibody-mediated hypersensitivity
Which antibody is produced in Type II Hypersensitivity
IgG and IgM
Prototypical disorders of Type II Hypersensitivity
Autoimmune hemolytic anemia Goodpasture syndrome Myasthenia Gravis Graves disease Pernicious anemia
What is the name of Type III Hypersensitivity
Immune complex-mediated hypersensitivity
Prototypical disorders of Type III Hypersensitivity
SLE Rheumatoid arthritis Some forms of glomerulonephritis Serum sickness Arthus reaction Polyarteritis nodosa
What is the name of Type IV Hypersensitivity
Cell-mediated hypersensitivity
Prototypical disorders of Type IV Hypersensitivity
Contact dermatitis
Multiple Sclerosis
Type I Diabetes
Tuberculosis
SLE autoantibodies
ANA Anti-dsDNA (double-stranded DNA) Anti-Sm (ribonuclear core protein, Sm antigen) Anti-RNP UI (ribonuclear protein) Anti-SS-A (Ro) Anti-SS-B (La) Anti-histones Antiphospholipid
Sjøgren syndrome autoantibodies
Anti-SS-A (Ro)
Anti-SS-B (La)
Systemic sclerosis autoantibodies
Anti-Scl-70 (DNA topoisomerase I)
Anti-centromere
Disorder with Anti-mitochondrial autoantibodies
Primary biliary cirrhosis
SLE symptoms
Photosensitivity, rash, ulcers of mouth and nose, pleuritis, pericarditis, arthritis, nephritis, anemia, thrombocytopenia, leukopenia
Cardinal signs of inflammation
Pain (Dolor) Redness (Rubor) Hot (Calor) Swelling (Tumor) Loss of function
Rheumathoid arthritis symptoms
Sunrise stiffness, soft feeling in joints, swelling in joints, synovitis, systemic involvement (fever, anemia, vasculitis), pulmonary fibrosis,
Which disease causes pannus formation
Rheumatoid arthritis
Which disease increases the risk of lymphoma?
Sjøgrens syndrome
Rheumatoid arthritis autoantibodies
Rheumatoid factor (IgM against Fc portion of IgG)
Anti-citrillinated
RANA
Sjøgrens syndrome symptoms
Xeropthalmia, xerstomia, keratoconjuctivitis, dryness in general
Scleroderma is a condition characterized by excessive deposition of what in the skin and multiple internal organs?
Collagen
Diffuse cutaneous scleroderma autoantibodies
Anti-Scl-70 (Anti-topoisomerase)
Limited cutaneous scleroderma autoantibodies
Anticentromere
Scleroderma symptoms
CREST syndrome (Limited) End organ involvement (Diffuse)
