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Virology > Part 5: DNA Viruses > Flashcards

Part 5: DNA Viruses Flashcards

1
Q
  • double strandedand enveloped
  • with severalantigens
A

Hepatitis B Virus

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2
Q
  • Australian antigen
  • surface antigen
A

HBsAg

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3
Q
  • core antigen
  • internal part
A

HBcAg

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4
Q
  • part of the same capsid polypeptide as the HBcAg
A

HBeAg

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5
Q

Pathogenesis
- replication occurs in hepatic cells and released by exocytosis

A

Hepadnaviridae

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6
Q

MOT: parenteral, sexual intercourse (esp. anal)

A

Hepadnaviridae

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7
Q
  • inflammatory condition of the liver
  • manifested by jaundice
  • may be asymptomatic
  • with carrier state
  • may be chronic and may lead to cirrhosis
A

Hepatitis

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8
Q

Host defense
- antibody and cell mediated responses are not protective

A

Hepadnaviridae

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9
Q

Diagnosis
- fever, headache, malaise, jaundice
- serology

A

Hepadnaviridae

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10
Q

Control
- screening of blood
- vaccine

A

Hepadnaviridae

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11
Q
  • over 80 species with about 40 are pathogenic to man
  • non-enveloped
  • icosahedral
A

Human Adenovirus

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12
Q

Pathogenesis
- produces cytopathic changes
- rounding, enlargement and aggregation

A

Adenoviridae

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13
Q

MOT: Droplet spray

A

Adenoviridae

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14
Q

5 diseases of Adenoviridae

A

Acute Febrile Pharyngitis, Pharyngeal, . Acute Respiratory Disease, Pneumonia, Gastroenteritis

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15
Q
  • common to children
  • indistinguishable from common colds and flu
A

Acute Febrile Pharyngitis

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16
Q
  • conjunctival Fever
A

Pharyngeal

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17
Q
  • common to military recruits
  • with rashes
A

Acute Respiratory Disease

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18
Q
  • complication
A

Pneumonia

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19
Q

Host defense
- no antibodies produced
- cytotoxic Tcells kill infected cells early

A

Adenoviridae

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20
Q

Epidemiology
- common to children below 6
- predominant in cold climate

A

Adenoviridae

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21
Q

Diagnosis
- Cell culture, serologic

A

Adenoviridae

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22
Q
  • difficult to prevent
  • vaccine is available for recruits
  • mild infection
A

Adenoviridae

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23
Q
  • coined from herpetic (___________)
  • enveloped
  • replication occurs in the _____________
  • may cause recurrent infections
  • with latency
A

Herpes Viridae
- coined from herpetic (spreading)
- enveloped
- replication occurs in the host’s nucleus
- may cause recurrent infections
- with latency

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24
Q
  • latency in nerve cells
  • HSV 1 &2, VZV
A

Neurotropic

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25
Q
  • latency in lymphocytes
  • EBV, CMV
  • some are associated with cancers
  • ________ are the natural host
A

Lymphotropic
- latency in lymphocytes
- EBV, CMV
- some are associated with cancers
- humans are the natural host

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26
Q

Pathogenesis
- commonly infects skin and mucous membranes (___, ___)
- internal infection (___, ___)
- produce intranuclear inclusions and __________________________

A

Herpes Viridae
Pathogenesis
- commonly infects skin and mucous membranes (HSV, VZV)
- internal infection (CMV, EBV)
- produces intranuclear inclusions and multinucleated giant cells

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27
Q

Epidemiology
- in lower socioeconomic groups (_____, ___, ___)

A

Herpes Viridae
Epidemiology
- in lower socioeconomic groups (HSV-1, CMV, EBV)

28
Q

Diagnosis
- characteristic lesions
- intranuclear inclusions onsmear
Tzanck Test

A

Herpes Viridae

29
Q
  • scraping of an ulcer base to look for ______ cells (multinucleated giant cells)
  • AKA: ________________, __________________ and the _________________
A

Tzanck Test
- scraping of an ulcer base to look for Tzanck cells (multinucleated giant cells)
- AKA: Tzanck smear, chickenpox skin test and the herpes skin test

30
Q

Control
- avoid contact
- vaccines
- Acyclovir

A

Herpes Viridae

31
Q
  • Gingivostomatitis
  • recurs as cold sores (____________)
  • herpetic __________
  • leads to __________ and blindness
  • whitlows
  • lesions on the ________
A

HSV – 1
- Gingivostomatitis
- recurs as cold sores (herpes labialis)
- herpetic keratitis
- leads to scarring and blindness
- whitlows
- lesions on the fingers

32
Q
  • genital Herpes
  • may lead to meningitis and encephalitis
  • MOT: sexual intercourse
A

HSV – 2

33
Q

Defenses of HSV 1 & 2
-___________ production is protective
- ___________
- __________________________

A

Defenses of HSV 1 & 2
-antibody production is protective
- recurrent
- cell mediated response

34
Q
  • Chickenpox
    -may progress to _____________
  • centrifugal rashes macules-papules-vesicles pustules-crusts
  • not prone to ________
A

Varicella
- Chickenpox
-may progress to pneumonia
- centrifugal rashes macules-papules-vesicles pustules-crusts
- not prone to scarring

35
Q
  • shingles
  • common to older people
  • lesions are found at the _________ and lumbar regions
A

Zoster
- shingles
- common to older people
- lesions are found at the thoracic and lumbar regions

36
Q

Disease
- characterized by jaundice, hepatosplenomegaly, CNS disorder

A

Cytomegalovirus (CMV)

37
Q
  • characterized by fever, fatigue, malaise and pharyngitis
  • kisser’s disease
A

Infectious Mononucleosis

38
Q
  • commonly associated with the infection of B-cell lymphocytes with the Epstein–Barr virus
A

Burkitt’s Lymphoma

39
Q
  • Roseola
  • rose-colored eruption in spots
A

HHV 6 (Roseolavirus)

40
Q
  • measles-like rashes in infants
A

HHV7

41
Q
  • Kaposi’s Sarcoma
  • _________________ of the skin and mucous membranes
  • reddish-brown or _________ tumorous plaques, macules, papules or nodules especially on the lower extremities
  • common to _____________
A

HHV8
- Kaposi’s Sarcoma
- neoplastic disease of the skin and mucous membranes
- reddish-brown or bluish tumorous plaques, macules, papules or nodules especially on the lower extremities
- common to AIDS patients

42
Q
  • replication occurs in the ___________
  • largest viruses
  • complex symmetry
  • no animal reservoir
A

Poxviridae
- replication occurs in the cytoplasm
- largest viruses
- complex symmetry
- no animal reservoir

43
Q

Pathogenesis
- systemic infection with characteristic rash
- MOT: ____________
- centrifugal rash formation
- rashes form scarring

A

Poxviridae
- MOT: inhalation

44
Q

E[idemiology
- eradicated

A

Poxviridae

45
Q

Diagnosis
- characteristic lesions
- electron microscopy (intracytoplasmic inclusions)

A

Poxviridae

46
Q

Control
- vaccination

A

Poxviridae

47
Q
  • A Variola that causes a severe disease (high mortality rate)
A

Variola Major

48
Q

Variola Disease

A

Smallpox

49
Q
  • used by Jenner to produce a vaccine for smallpox
A

Vaccinia

50
Q

Vaccinia Disease

A

Cowpox

51
Q

Orf Disease

A

Sheep and goat pox

52
Q
  • characterized by smooth, waxy tumorlike nodules on the face, trunk and limbs
A

Molluscipoxvirus

53
Q

Molluscipoxvirus Disease

A

Molluscum contagiosum

54
Q
  • non-enveloped and icosahedra
A

Papovaviridae

55
Q

A Papovaviridae on epithelial cells of the skin and mucous membranes

A

Human Papilloma Virus (HPV)

56
Q

Pathogenesis
- causes warts
- MOT:______________

A

Human Papilloma Virus (HPV)
- MOT: direct contact

57
Q

Epidemiology
- common to children and young adults

A

Human Papilloma Virus (HPV)

58
Q

Diagnosis
- condylomata acuminata (genital warts) are very distinguishable
- histology, molecular methods

A

Papovaviridae

59
Q
  • freezing, cauterization, surgery, laser vaporization
A

Papovaviridae

60
Q
  • first isolated from the urine of arenal allograft recipient receiving ___________________________
A

BKV
- first isolated from the urine of arenal allograft recipient receiving immunosupressive drugs

61
Q
  • first isolated from the brain of a patient with progressive ____________________________
A

JCV
- first isolated from the brain of a patient with progressive multifocal leukoencephalopathy

62
Q

Epidemiology
- 70 – 90% of adults are exposed to these viruses

A

JC and BK Polyoma Virus

63
Q
  • only DNA virus pathogenic to man with a single stranded genome
  • smallest icosahedral DNA virus
  • endemic zoonotic infection
A

Parvoviridae

64
Q
  • Genus Erythrovirus
A

Parvovirus B-19

65
Q

Pathogenesis
- causes Erythema infectiosum
- AKA: ______________/ _____________________
- rashes begin on the ______ (centripetal)

A

Parvoviridae
- AKA: fifth disease/ slapped cheek disease
- rashes begin on the cheeks (centripetal)

Virology (6 decks)

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