Part 3: ART

Question 1

Primary infertility:

Answer 1

• never had a pregnancy and never able to conceive.

Question 2

Secondary infertility:

Answer 2

• Pregnancy previously achieved.
• Difficulty achieving another pregnancy.

Question 3

Function of Clomiphene (drug):

Answer 3

• ERα antagonist within hypothalamus.

Question 4

Steps in artificial reproduction via GnRH stimulation:

Answer 4

1. Give Clomiphene; ERα antagonist.
2. E2 negative feedback blocked; FSH secreted.
3. Multiple dominant follicles produced.
4. Ovulated oocytes harvested.
5. Oocytes artificially inseminated.
6. Feritlized oocytes reimplanted into endometrium.
7. Progesterone administered into first trimester.

Question 5

Steps in artificial reproduction via GnRH suppression:

Answer 5

1. Give clomiphene or luprolide to disrupt GnRH pulsatility.
2. Give exogenous FSH.
3. Multiple dominant follicles produced.
4. Give hCG (LH analog) to cause ovulation.
5. Ovulated oocytes harvested.
6. Oocytes artificially inseminated.
7. Feritlized oocytes reimplanted into endometrium.
8. Progesterone administered into first trimester.