Part 2 Flashcards

1
Q

What is the possible late complication of measles infection (several years after the acute infection)?

A

SSPE – subacute sclerosing panencephalitis

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2
Q

What is the portal of entry of the viruses belonging to Paramyxoviridae?

A

Respiratory tract – aerosol infection

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3
Q

Which virus is the most common cause of severe viral lower respiratory tract infections in infants and small children?

A

respiratory syncitial virus (RSV)

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4
Q

What are the possible complications of adulthood mumps virus infection? Specify at least 2 of them!

A

Orchitis, meningitis, pancreatitis

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5
Q

What is the route of infection of rabies virus? How does rabies virus spread in the infected body?

A

By the bite of a rabid animal, (rarely by infectious aerosol) spread of the virus in the host – along the axons

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6
Q

What medication does a person need after exposure to rabies virus?

A

Active immunization – human diploid cell vaccine (killed virus) and passive immunization – rabies immune globulin

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7
Q

What is the portal of entry of polioviruses? Which areas of the central nervous system are affected by poliovirus infection?

A

oropharynx and gastrointestinal tract
damage in motor neurons in the anterior horn of the spinal cord + brain stem

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8
Q

Which human viruses belong to the Enterovirus genus?

A

Polioviruses, coxsackie viruses, echoviruses, enteroviruses 68 - 71

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9
Q

Mention at least 4 diseases caused by Coxsackie viruses!

A

febrile rashes, herpangina, myocarditis, pericarditis, meningitis, pleurodynia, hand-foot-and-mouth disease

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10
Q

What disease do rotaviruses cause? At which age?

A

gastroenteritis in young children

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11
Q

List the 3 antigens of hepatitis B virus against which antibodies may develop during or after the acute phase of infection?

A

HBsAg, HBeAg, HBcAg

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12
Q

Which hepatitis B-specific antibody is almost never present in chronic hepatitis?

A

Anti-Hbs

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13
Q

What are the main modes of transmission of HBV (hepatitis B virus) infection?

A

Sexual contact; perinatally from mother to newborn; by blood or blood products

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14
Q

What are the 2 serological markers that are necessary and sufficient to prove acute hepatitis B virus infection?

A

HBsAg, Anti-HBc IgM

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15
Q

Describe the active and passive prophylaxis against hepatitis B!

A

active immunization: recombinant HBsAg vaccine
passive immunization: HBIG (hepatitis B immune globulin)

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16
Q

Which hepatitis viruses are acquired orally?

A

HAV, HEV

17
Q

Which hepatitis viruses are acquired via parenteral routes?

A

HBV, HCV, HDV, (HGV)

18
Q

Mention 4 diseases that can be caused by adenoviruses!

A

pharyngitis, pharyngoconjunctival fever, acut respiratory disease, bronchitis, atypical pneumonia, hemorrhagic cystitis, gastrointestinal infection

19
Q

What is the portal of entry of mumps virus?

A

Upper respiratory tract

20
Q

Mention at least two viruses frequently causing pneumonia!

A

RSV, influenza virus A and B, parainfluenza virus, adenoviruses, coronavirus SARS-CoV2

21
Q

What is the causative agent of subacute sclerosing panencephalitis (SSPE)?

A

Measles virus

22
Q

What is(are) the nature(s) of antigen(s) in the combined vaccine against measles, mumps and rubella?

A

live attenuated viruses

23
Q

What is the nature of antigen in the rabies vaccine for human use?

A

killed virus

24
Q

Which viral variants are included in the human influenza vaccine?

A

The vaccine contains 2 influenza A strains (H3N2, H1N1) and 1or 2 influenza B strain(s).

25
Q

What does the vaccine against hepatitis B contain?

A

Subunit vaccine, containing HBsAg

26
Q

What is the nature of the antigens in the different types of poliovirus vaccine?

A

IPV (inactivated polio vaccine): killed viruses (types 1, 2, and 3)
OPV (oral polio vaccine): live attenuated viruses (types 1, 2, and 3)

27
Q

What is the causative agent of PML (progressive multifocal leucoencephalopathy)?

A

JC virus (Polyomaviridae)

28
Q

What are the possible manifestations of fetal infections caused by rubella virus? Specify at least 3 of them!

A

Congenital malformations involving the heart (patent ductus arteriosus, septum defects), the eyes (cataract, glaucoma) and the brain (deafness, mental reardation).

29
Q

Mention 3 human prion diseases!

A

Kuru, Creutzfeldt-Jacob disease, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia

30
Q

What is the nature of the immune response in diseases caused by prions?

A

There is no immune response, as prions are self proteins.