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Signal transduction > Part 1: Aspects of signal transduction > Flashcards

Part 1: Aspects of signal transduction Flashcards

1
Q

Juxtacrine mode of transduction

A

direct physical contact

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2
Q

Juxtacrine sender cells

A

cells in most body tissues (cardiac muscle, skin, retinal neurons)

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3
Q

Juxtacrine Target cells

A

cells adjacent to sender cells

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4
Q

Juxtacrine types

A

Surface protein/receptor interaction–> binding of membrane bound surface protein of sender to target

Gap junction-> cytoplasm to cytoplasm exchange of intracellular ions/molecules thru tubular protein structures

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5
Q

Connexon

A

1 connexon = 6 connexins
each connexin has 4 transmembrane domains, 2 extracellular loops
-loops aid in connexon-connexon docking for gap junctions

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6
Q

Endocrine mode of transduction

A

release of secreted molecules into bloodstream

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7
Q

endo sender cells

A

specialized in glandular tissues

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8
Q

endo target cells

A

cells in various tissues that express specific receptors

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9
Q

endo signal molecules

A

hormones

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10
Q

endo range

A

long distance

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11
Q

endo concentraion

A

very low (10^-12-10^-9M)

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12
Q

endo receptors

A

very high affinity

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13
Q

endo on/off response

A

slow (minutes to hours)

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14
Q

Paracrine mode of transduction

A

release and diffusion of secreted molecules into extracellular space

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15
Q

para sender cells

A

cells in various tissues throughout the body

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16
Q

para target cells

A

neighboring cells

17
Q

para signal molecules

A

local mediators (growth factors, cytokines)

18
Q

para range

A

short distance

19
Q

para concentration

A

low to high (10^-9-10^-6M)

20
Q

para on/off response

21
Q

synaptic mode of transduction

A

release and diffusion of secreted molecules into synaptic cleft (extreme form of paracrine signaling)

22
Q

synaptic sender cells

A

neurons (axon extension)

23
Q

synaptic target cells

A

neurons, muscle cells

24
Q

synaptic signal molecules

A

neurotransmitters

25
Q

synaptic range

A

very short

26
Q

synaptic concentration

A

very high (10^-6-10^-3M)

27
Q

synaptic on/off response

A

very rapid (milliseconds)

28
Q

autocrine mode of transduction

A

release of secreted molecules in vicinity of cells own surface (form of para signaling)

29
Q

autocrine sender cells

A

cells in various tissues throughout body

30
Q

autocrine target cells

A

same cell as sender cell

31
Q

autocrine signal molecules

A

large proteins (growth factors, cytokines)

32
Q

autocrine range

A

short distance

33
Q

autocrine concentration

A

low to high (10^-9-10^-6M)

34
Q

autocrine receptors

A

low to high affinity

35
Q

autocrine on/off response

Signal transduction (5 decks)

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