Parkinsons- Week 3 Flashcards
PD definition
slowly progressing neurodegenerative disorder with insidious onset of asymmetric resting tremor, bradykinesia, hypokinesia, and rigidity, sometimes with postural changes
pathophysiology of PD
nerve cells in the SUBSTANTIA NIGRA send out fibers to the CORPUS STRATIA, gray and white bands of tissue located in both sides of the brain (direction is important, from substantia to corpus)
next step of patho
there the cells release dopamine, an essential neurotransmitter. Loss of dopamine in the corpus stratia is the primary defect in PD.
pathological changes in PD
dark “moustache” that represents the substantia nigra almost disappears
classical round proteinaceous body- known as Lewy body- considered pathological hallmark of PD**
incidence/ epidemiology of PD
1% of population worldwide
mean age of onset 65 years
equally affects men and women
5- 10% get it before age 40
the why’s of PD
older age
smoking
first degree relative (most cases are sporadic but there is a genetic component)
more patho of PD
destruction of neural cells in the substantia nigra pars compacta (midbrain) that secrete dopamine = loss of dopamine and dopamine receptor sites (70- 80% of neurons must be dead for symptoms to appear)
Lewy bodies- pathologic hallmark but only found on autopsy
diagnosis of PD based on
clinical evaluation
parkinsonism
any group of nervous system disorders with symptomts similar to PD
motor parkinsonism
is an essential criterion of PD and requires both of the following: bradykinesia & rest tremor or rigidity
the true “gold standard” for diagnosis for PD
neuropathologic examination. There are no physiologic tests of blood test for confirming diagnosis of PD
Diagnosis of PD based on clinical eval- what is the work up?
history (meds, trauma, family) physical exam CT, MRI (r/o other possible causes) response to Levodopa PD vs. Parkinsonism consult neurology
the diagnosis of clinically established PD requires ALL of the following
the presence of parkinsonism
no absolute exclusion criteria (no way to say its not PD)
at least 2 supportive criteria
no red flags
clinically probable diagnosis of PD
the presence of parkinsonism
no absolute exclusion criteria
the presence of red flags must be counterbalanced by supportive criteria
- if one red flag is present, there must also be at least one supportive criterion
- if 2 red flags, at least 2 supportive criteria are needed
- no more than 2 red flags are allowed for this category
clinical presentation- idiopathic PD
bradykinesia
plus tremor (most common sign)
or rigidity (2 of the 3 of bradykinesia, tremor, rigidity need to be present)
postural instability (occurs late in disease)
resting tremor
asymmetry (one side more affected than the other)
good response to Levodopa
supportive diagnosis
unilateral onset
masked face (decrease in spontaneous facial expression/ flat expression)
hypophonia, monotonous tone (quiet)
gait disorder, falls (forward tilt of trunk, shuffling gait)
flexed posture
reduced arm swinging
persistent asymmetry throughout the course of the disease with the side of onset most affected
bradykinesia
generalized slowness of movement
may be described by pt as “weak, incoordination, tired, stiffness”- all words used to describe the decreased ability to initiate voluntary movement
typically starts distally in arms with decreased manual dexterity of fingers
in legs: dragging, shorter/ shuffling steps, unsteadiness
bradykinesia is eventually seen in all PD patients and is the most common feature
also is the most difficult symptom to describe for patients
tremor
resting tremor, usually unilateral
**most common PRESENTING symptom- most noticeable when the tremulous body part is supported by gravity and not engaged in purposeful activities
can be intermittent
side affected usually is the more affected side throughout disease course
usually starts unilateral in 1 hand
can involve legs, lips, jaw and tongue
big caution: the majority of people with tremor do NOT have PD: essential tremor (usually b/l and intention), MS (intention), cerebellar dysfunction (usually intention and with other cerebellar signs)
rigidity
increased resistance to passive movement about a joint
occurs in approximately 90% of patients with PD
often begins unilaterally, typically same side as tremor
cogwheel rigidity
ratchet pattern of resistance and relaxation
leadpipe rigidity
present throughout movement