Endocrine Up to Dates Flashcards
The most common clinical presentation of primary hyperparathyroidism
asymptomatic hypercalcemia detected by routine blood work
Clinical manifestations of PHPT
Skeletal manifestations and kidney stones (nephrocalcinosis)
Physical findings in PHPT
usually no physical findings. may have a palpable neck mass but that is most likely a thyroid nodule or parathyroid carcinoma
Normocalcemic primary hyperparathyroidism
PTH levels are elevated but the serum calcium is normal. For this diagnosis, all secondary causes for hyperparathyroidism must be ruled out and ionized calcium levels should be normal
Parathyroid crisis
Very rare condition. Consists of severe hypercalcemia — above 15 and s/s of hypercalcemia - CNS dysfunction. AMS, bone disease, kidney stones. Can be caused by a life threatening illness, volume loss or an infarction of a parathyroid adenoma
Classic PHPT
Combined effects of increased PTH secretion and hypercalcemia. Bones, stones, abdominal moans and psychic groans.
Prolonged PTH excess leads to
kidney stones and bone disease
Symptoms of hypercalcemia
anorexia, nausea, constipation, polydipsia, polyuria
Most common complication of PHPT
kidney stones
Ostitis Fibrosa cystica
Most often in those with severe disease or parathyroid carcinoma. Classic manifestation of PHPT bone disease. Characterized by bone pain and radiographically by subperiosteal bone resorption on the radial aspect of the middle phalanges, tapering of distal clavicles and a salt and pepper appearance of the skull, bone cysts, brown tumors of the long bones. Bone tumors are from excess osteoclast activity.
Nephrolithiasis PHPT
Kidney stones. Most often comprised of calcium oxalate.
Neuromuscular s/s PHPT
Weakness and fatigue. Improved when parathyroid is removed. Bone pain, osteoporosis/osteopenia
Neuropsychiatric symptoms PHPT
lethargy, depressed mood, psychosis, decreased social interaction, cognitive dysfunction. Decreased concentration, confusion, stupor, coma
Renal disease s/s PHPT
decrease concentrating ability with a GFR less than 60
Cardiovascular s/s PHPT
HTN, arrhythmia, ventricular hypertrophy and vascular and valvular calcification
Rhem s/s PHPT
hyperuricemia, gout, pseudogout in wrist and knees
Lab findings PHPT
hypophosphatemia, decreased mg, anemia which responds to a parathyroidectomy
Causes of secondary hyperparathyroidism
Renal failure: hyperphosphatmia/impaired calcitrol production. Calcium malabsorption from vitamin D deficiency, bariatric surgery, celiac disease, pancreatic disease (fat malabsorption). Renal calcium loss from hypercalciuria or loop diuretics. Inhibition of bone resorption through biphosphonates or hungry bone syndrome
PHPT s/s
bone disease, kidney stones, hypophosphatemia, increased production of calcitol (Vitamin D3), proximal renal tubular acidosis, hypomagnesmia, hyperuricemia, gout, anemia
GI s/s PHPT
Anorexia, n/v, constipation, pancreatitis, Peptic ulcer disease
Renal s/s PHPT
polyuria, polydipsia, nephrolithiasis, nephrocalcitonosis, distal tubular acidosis, neprogenic DI, acute and chronic renal insufficiency
cardiovascular s/s PHPT
shortened QT interval, bradycardia, hypertension
Treatment options for PHPT
surgical intervention vs. observation
Who is surgery recommended for
Hyperparathyroidism with symptomatic disease (polyuria, polydipsia, fragility fx, kidney stones, osteoporosis, pud, pancreatitis, gerd, neurodysfunction)
Asymptomatic patient who needs surgery
< 50, likely to progress into symptomatic based on GFR, T score < 2.5 (osteoporosis) and calcium greater than 1mg/dL above normal
Parathyroid exploration
PHPT as a result of parathyroid cancer or parathyroid crisis, or with recurrent primary hyperparathyroidism
Contraindications to parathyroidectomy
contralateral recurrent laryngeal nerve injury and symptomatic cervical disc disease
Complications of parathyroidectomy
failure to achieve cure of hypercalcemia, hematoma with airway compromise, hypoparathyroidism and laryngeal nerve injury
subclinical hyperthyroidism
no clinical symptoms just a low TSH
overt hyperthyroidism
dramatic symptoms – lability, tremors, palpitations, anxiety, sweaty, increased heat intolerance, urinary frequency, hyperdefecation,
mild hyperthyroidism
symptoms only to a few organ systems, like weight loss, new afib, menstrual disorders
symptoms of hyperthyroidism is the older adult
may have more cardiac and resp symptoms - tachycardia, afib, DOE, apathetic thyrotoxicosis (no symptoms except weakness and asthenia)
physical exam with hyperthryoidism
hyperactivity, rapid speech. lid lag/stare. warm skin. thin hair. tachycardia. afib irregular pulse. systolic hypertension. tremor. hyperreflexia. (exophalmus. periorbital edema and limited eye movement only with graves disease)
Subclinical hyperthyroid
low tsh but normal t4 t3 free t3 most do not have any clinical s/s of hyperthyroidism Can be mild graves or a multinodular goiter
primary hyperthyroidism labs
low tsh, high t3 and/or t4
t3 toxicosis
greater increase in t3 than t4, seen in Graves or a nodular goiter. Due to increased t3 secretion and an increased extrathyroidal conversation of t4 to t3