Parkinsons meds (French) (Midterm)

Question 1

The addition of carbidopa to levodopa:
A. Increases the rate of GI absorption to levodopa
B. Makes more levodopa available for transport to the brain
C. Increases the severity of levodopa-induced nausea and vomiting
D. All of the above

Answer 1

B. Makes more levodopa available for transport to the brain

Question 2

The majority of patients treated with carbidopa/levodopa experience motor fluctuations and dyskinesia after: 
A. 6-8yrs
B. 2-5yrs
C. 3-5yrs
D. 5-8yrs

Answer 2

D. 5-8yrs

Question 3

Dopamine agonists:
A. Are less effective than levodopa in treating the motor symptoms of Parkinson’s disease
B. Are less likely than levodopa to cause dyskinesia
C. Can cause lower extremity edema
D. All of the above

Answer 3

D. All of the above

Question 4

Dopamine agonists should generally not be used in patients with: 
A. Dyskinesia
B. Motor fluctuations
C. Dementia
D. QT-interval prolongation

Answer 4

C. Dementia

Question 5

COMT inhibitors:
A. Increase peak serum concentrations of levodopa
B. Prolong the half-life of levodopa
C. Stimulate regeneration of dopaminergic neurons in the substantial nigra
D. Inhibit catabolism of dopamine in the brain

Answer 5

B. Prolong the half-life of levodopa

Question 6

MAO-B inhibitors can:
A. Decrease levodopa-induced dyskinesia
B. Be used as monotherapy in early Parkinson’s disease
C. Be used safely with sympathomimetic amines
D. All of the above

Answer 6

B. Be used as monotherapy in early Parkinson’s disease

Question 7

Impulse control disorders can occur with which of the following drugs used for treatment of Parkinson's disease?
A. Levodopa
B. Dopamine agonists
C. Istradefylline
D. All of the above

Answer 7

D. All of the above

Question 8

The most effective treatment for the motor symptoms of Parkinson's disease is: 
A. Dopamine agonist
B. COMT inhibitor
C. Carbidopa/levodopa
D. Amantadine

Answer 8

C. Carbidopa/levodopa

Question 9

After 5-8 years of levodopa treatment, the majority of patients develop: 
A. Nausea and vomiting
B. Cognitive impairment
C. Severe constipation
D. Motor fluctuations and dyskinesia

Answer 9

D. Motor fluctuations and dyskinesia

Question 10

Which of the following could reduce the efficacy of levodopa when taken concurrently?
A. MAO inhibitor
B. SSRI antidepressant
C. Antipsychotic
D. Fluoroquinolone

Answer 10

C. Antipsychotic

Question 11

A 46y/o man with mild Parkinson’s disease is questioning his neurologist’s recommendation that he be treated with pramipexole, a dopamine agonist, instead of carbidopa/levodopa. You could tell him that:
A. Dopamine agonists are the most effective treatment for Parkinson’s disease
B. Dopamine agonists are effective in early, mild disease
C. Dopamine agonists have no side effects
D. He should get a second opinion from another neurologist

Answer 11

B. Dopamine agonists are effective in early, mild disease

Question 12

COMT inhibitors:
A. Prolong the half-life of levodopa without increasing its peak serum concentrations
B. Are used as monotherapy in Parkinson’s disease
C. Can cause serious renal toxicity
D. Decrease the risk of dyskinesia in patients taking levodopa

Answer 12

A. Prolong the half-life of levodopa without increasing its peak serum concentrations