Parkinson's Studies

Question 1

Fahn 2003

Answer 1

Cardinal symptoms of PD are rigidity, bradykinesia, resting tremor etc.

Question 2

Dickson 2009

Answer 2

Lack of dopamine and build up of Lewy bodies

Question 3

Rodriguez-Oroz et al. 2009

Answer 3

Decreased nigrostriatal input leads to increase in net inhibitory output fro, global pallidus, repressing initiation of movement

Question 4

Tolosa et al. 2006

Answer 4

Loss of smell predates substantia nigra pathology - PD may start in the olfactory bulb

Question 5

Langston et al. 1983

Answer 5

Induced Parkinson’s with MPTP intravenous drug use

Question 6

Priyadarshi et al. 2000

Answer 6

Pesticides double risk

Question 7

Zimprich et al. 2004

Answer 7

LRRK2 mutations on chromosome 12

Question 8

Lücking et al. 2000

Answer 8

Parkin mutation - up to 50% of early onset is caused by this mutation

Question 9

Bembi et al. 2003

Answer 9

Gaucher’s disease puts you at risk - lipid storage disorder, poor response to levodopa

Question 10

Rascol et al. 2000

Answer 10

Levodopa - side effects in 50-80% of population - global pallidus is over inhibited, so motor cortex is under inhibited (dyskinesia) - DA agonists and supplement with levodopa

Question 11

Olanow et al. 2000

Answer 11

DBS - electrodes in midbrain stimulate and inhibit

Question 12

Piccini et al. 1999

Answer 12

Stem cell research - restore striatal pathways in animals

Question 13

McKeith et al. 2000

Answer 13

High prevalence of dementia with PD - Lewy bodies share same cellular pathway

Question 14

Queen Square brain bank

Answer 14

Diagnostic criteria for Parkinson’s 10-25% later reclassified