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Pharmacology Exam 7 > Parkinson's Disease > Flashcards

Parkinson's Disease Flashcards

1
Q

Symptoms of Parkinson’s

A

Tremor
Rigidity
Akinesia
Postural instability

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2
Q

Which symptom is the most responsive and debilitating?

A

Bradykinesia

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3
Q

Which symptom is the most difficult to treat and appears late in PD?

A

Postural instability

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4
Q

Initial treatment

A

Treat bradykinease and disability, control symptoms

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5
Q

Second stage treatment

A

Patient now has dyskinesia, need to treat with L-DOPA

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6
Q

Prodrug metabolized to DA by L-amino acid decarboxylase in the brain

A

L-DOPA

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7
Q

Transporter of L-DOPA

A

L-amino transporter

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8
Q

Main symptom that L-DOPA treats

A

Bradykinesia, restless leg syndrome

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9
Q

Side effect of L-DOPA

A

Impulsive behavior (worsened by carbidopa), off and on phenomenon (fluctuation between dykinesia with longterm use)

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10
Q

What is the MOA of Carbidopa?

A

Prevent metabolism of L-dopa in the periphery

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11
Q

Benefit of carbidopa

A

Increases L-DOPA reaching brain by 10%

Allow reduction of L-DOPA by 75%

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12
Q

Side effects of carbidopa

A

Increased CNS side effects of L-DOPA

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13
Q

Which dopamine receptor agonist is a direct D2 receptor that does not require any metabolism?

A

Pramipexole

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14
Q

Which DA receptor agonist is used to rapidly treat “Motor fluctuation” syndrome and hypomobility in advanced PD?

A

Apomorphine

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15
Q

Which PD drug is associated with a strong-emetic reaction?

A

Apomorphine

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16
Q

What is the MOA of Selegiline?

A

MOA-B selective irreversible inhibitor

Prevent degradation of DA in the CNS, prolong effects of L-DOPA

17
Q

Which PD drug is associated with having possible disease modifying effects?

A

Selegiline

18
Q

Which drug is used in combination with L-DOPA and Carbidopa to reduce motor fluctuations?

A

Selegiline

19
Q

Is Selegiline associated with HTN crisis?

A

No

20
Q

What is the MOA of Entacapone

A

Reversible inhibitor of COMT

Prolong effects of L-DOPA and carbidopa

21
Q

How must Entacapone be administered?

A

In combination with L-DOPA and carbidopa

Cannot be administered alone

22
Q

Which drug is used for patients with tremor and lacking bradykinesia?

A

Trihexyphenidyl

23
Q

Which drug is associated with cognitive dysfunction?

A

Trihexyphenidyl

24
Q

Which drug blocks the M3 receptors to improve symptoms in tremor patients?

A

Trihexyphenidyl

25
Q

Which PD drug is an anti-viral?

A

Amantidine

26
Q

Which PD drug is associated with cognitive impairment, livedo reticularis (purple skin), and ankle edema?

A

Amantidine

Pharmacology Exam 7 (8 decks)

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