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Module 4 > Parkinson's Disease > Flashcards

Parkinson's Disease Flashcards

0
Q

Catechol O-Methyltransferase inhibitors

A

Entacapone

Tolcapone

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1
Q

Dopa decarboxylate inhibitors

A

Carbidopa (Sinemet)

Benserazide (Madopar)

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2
Q

DBS target for tremor

A

Thalamus

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3
Q

DBS target for dyskinesia

A

Pallidum (GPi)

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4
Q

DBS for akinesia and rigidity

A

Subthalamic nucleus

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5
Q

Dopamine agonists

A

Ropinirole
Rotigotine patch
Pramipexole
Apomorphine

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6
Q

Monoamine oxidase B inhibitors

A

Selegiline

Rasagiline

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7
Q

Accessory therapies

A

COMT inhibitors
Amantidine (early PD; dopamine sparing agent)
Anticholinergics (benzhexol)

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8
Q

Apomorphine administration

A

APO-go pen 6 off periods per day

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9
Q

Initial treatments?

A

Levodopa - most effective, best tolerance, but requires multiple doses a day and has long term side effects: dyskinesia

Dopamine agonists - less effective, once daily but side effects include swollen legs, hallucinations, psychiatric disturbances (paranoia, pathological gambling, hypersexuality)

Monoamine oxidase B inhibitors - least effective, but once daily and not associated with side effects

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Module 4 (4 decks)

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