Parkinson’s Disease

Question 1

Parkinson’s Disease

Answer 1

A genetic disease that affects the nervous system

Question 2

3 Main Symptoms

Answer 2

Involuntary shaking of particular parts of the body (tremor)
Slow Movement
Stiff and inflexible muscles

Question 3

Caused by?

Answer 3

Neurones have lower than normal levels of the neurotransmitter dopamine

Question 4

L-Dopa

Answer 4

Replaces the dopamine that is lost

Question 5

Why can’t dopamine be used to treat it?

Answer 5

Cannot cross the blood-brain barrier (BBB)

Question 6

Why does L-Dopa work?

Answer 6

L-Dopa can cross the BBB and can be used by the neurones to make dopamine

Question 7

Dopamine is made in the axon terminals and packed into ________ ________

Answer 7

Synaptic Vesicles

Question 8

Fusion of synaptic vesicles releases dopamine molecules into the ________ _____

Answer 8

Synaptic Cleft

Question 9

Dopamine molecules diffuse across and bind to _________ on the postsynaptic membrane, triggering a response

Answer 9

Receptors

Question 10

Dopamine leaves the receptors and move back into the ___________ _______

Answer 10

Presynaptic Neurone

Question 11

Some dopamine is repackaged into ________

Answer 11

Vesicles

Question 12

Some dopamine is broken down by the enzyme Monoamine Oxidase (___)

Answer 12

MOA