Parkinson's Disease Flashcards
what are the common symptoms of Parkinson’s disease?
- Dyskinesia (involuntary, erratic, writhing movements of the face, arms, legs or trunk)
- Rigidity
- Slow Shuffle
- Tremor
what part of the brain is most affected in Parkinson’s?
basal ganglia, particular the substania nigra pars compacta
what is the substania nigra pars compacta?
the source of the important nigrostriatal dopamine pathway
+ motor movement
what is the basal ganglia responsible for?
a group of subcortical nuclei responsible primarily for motor control, as well as other roles such as motor learning, executive functions and behaviors, and emotions.
what happens to the basal ganglia and substance nigra par compact in Parkinson’s?
dopamine secreting neurones begin to die and break down affecting the basal ganglia system
how does dopamine neurons beginning to die affect an individual?
- voluntary movements primarily affected
- all about control and timing of movements -> issues with starting and initiating movement
neuropathy of parkinson’s
- nigro-striatal pathway degeneration leading to a depletion of striata dopamine
- some degeneration of other dopamine pathways too - midbrain affected too
what is the striatum?
a cluster of interconnected nuclei that form a part of the basal ganglia. It is involved in decision making functions, such as motor control, emotion, habit formation, and reward
what would happen if you cut open the main brain area?
generally black because of the melanin
what were the treatment options prior to 1960?
no effective treatment available
what did they realise when Parkinson’s was an attribute of dopamine involvement?
lead to the use of drugs which increase brain dopamine levels
what is the issue with dopamine, itself?
cannot cross blood-brain barriers
How we ensure that the brain gets dopamine?
precursor, L-Dopa, enters the brain and is converted into dopamine
what are issues with dopamine?
causes severe side effects (dyskinetic movements, psychotism)
what treatment may be given if an individual is younger?
dopamine agonist