parkinson's and huntington's drugs Flashcards
Selegeline:
a. must never be combined with L-dopa
b. decreases synaptic dopamine levels
c. is a selective MAOB inhibitor
d. can speed up the progression of the Parkinson’s disease
c. is a selective MAOB inhibitor (prevents dopamine metabolism)
Which of the following statements concerning the use of L-dopa for Parkinsonian patients is CORRECT?
a. It is a specific inhibitor of MAOB (monoamine oxidase B)
b. It has a short half life (3-4 hrs)
c. It prevents the activation of dopamine D2 receptors
d. Peripherally acting dopa decarboxylase inhibitors prevent its action
b. It has a short half life (3-4 hrs)
Pramipexole is a:
a. dopamine D2 receptor agonist
b. MAO inhibitor
c. peripheral dopa decarboxylase inhibitor
d. dopamine releaser
a. dopamine D2 receptor agonist
what is levodopa administered with and why?
carbidopa (inhibit peripheral dopa decarboxylase)
prevent conversion of L-dopa to dopamine in the periphery
what is Bromocriptine?
DA receptor agonist
what is Pramipexole?
DA receptor agonist
why does apomorphine have a lower risk of dyskinesia than levodopa?
longer half-life
what is Entacapone?
COMT inhibitor (prevent levodopa from being converted to 3-OMD –> more cross BBB to reach brain)
what is Benzatropine?
muscarinic antagonist (inhibit influence of cholinergic neurons within striatum)
what is baclofen and what is it indicated in?
GABA agonist (indicated in Huntington’s)
which of the following medications is contraindicated in Parkinson’s disease?
a. bromocriptine
b. domperidone
c. entacapone
d. metoclopramide
d. metoclopramide (D2 receptor antagonist) –> extrapyramidal side effects (can cross BBB)
which of the following Parkinson’s drugs causes nausea and vomiting? (due to its effects in the brain)
a. Benztropine
b. Selegiline
c. Entacapone
d. Apomorphine
d. Apomorphine
(due to activation of chemoreceptor trigger zone)
what is benserazide?
dopa decarboxylase inhibitor (same as carbidopa)
how is levodopa administered?
orally
Select, from the following list, the MOST LIKELY side effect of a dopamine agonist.
A. Antiemetic
B. Bradykinesia
C. Dry mouth
D. Hallucinations
E. Rigidity
D. Hallucinations
