Parkinson's

Question 1

What is Parkinson’s?

Answer 1

degenerative movement disorder caused by reduction in dopamine in substantial nigra in basal ganglia

Question 2

What causes Parkinson’s?

Answer 2

Idiopathic, drugs, environmental, genetics

Question 3

What is the presentation of Parkinson’s?

Answer 3

resting tremor, bradykinesia, rigidity, forward posture, reduced arm swing, shuffling gait

Question 4

What is the difference between a Parkinson’s tremor and a benign essential tremor?

Answer 4

Parkinson’s is asymmetrical, worse at rest, has other Parkinson’s features and doesn’t change with alcohol

Question 5

How to diagnose Parkinson’s?

Answer 5

Made based on clinical findings, response to levodopa

Question 6

Treatment of Parkinson’s?

Answer 6

Dopamine agonist (ropinirole)
L-dopa/ Levodopa (can cause end-dose fading)
MOA-B inhibitors (selegiline)