Multiple Sclerosis Flashcards
1
Q
What is MS?
A
chronic progressive condition that involves demyelination of myelinated neurones in CNS. Oligodendrocytes are targeted.
2
Q
What causes MS?
A
genetics, EBV, low vitamin D, smoking, obesity
3
Q
What are the signs and symptoms of MS?
A
optic neuritis, Uhtoff’s phenomenon (symptoms worse in the heat), Lhermitte’s Sogn (electric shock sensation), trigeminal neuralgia, paraesthesia, incontinecne, Bell’s palsy, limb paralysis, spasticity, weakness
4
Q
What are the sub-types of MS?
A
Relapsing-remitting
Primary progressive
Secondary progressive
5
Q
How to diagnose MS?
A
MRI (lesions)
Lumbar puncture: oligoclonal bands in CSF
Visual evoked Potentials
6
Q
How to manage MS?
A
MDT, disease modifying drugs (baclofen, betaferon) and biological therapy, relapses (methylprednisolone)
