Parenteral Depot Preparations

Question 1

What are the benefits of long acting preparation ?

Answer 1

1.maintain constant drug release

2.less frequent administrations

3.more convenience

4.enhanced compliance on the patients behalf

5. For local and systemic treatment

Question 2

What are the different types of long acting preparations?

Answer 2

-oily solutions/suspensions
-aqueous suspensions
-lipid emulsions
-rate controlling membranes polymeric based membranes
-osmotic based membranes
-in situ forming system
-liposomes
-Nanoparticulates

Question 3

What drugs come as a oily solution?

Answer 3

Contraceptive agents
Hormone
Antipsychotic agents

Question 4

What vehicles can be used in oily solutions?

Answer 4

-vegetable oils
castor oil
various fatty acid compositions
Acceptable chemical stability
Prone to heat and light

-synthetic fatty acid esters e.g. isopropyl myristate

Question 5

What considerations need to be mad we when using oily solutions?

Answer 5

Vehicle viscosity

Drug solubility

Drug partition between oil and aqueous media