Parathyroid Flashcards
What is the synthetic PTH hormone (rhPTH) drug on the market? Frequency of use?
Forteo
Chronic leads to bone break down
Intermittent therapy leads to bone formation
What are some preparations of calcitonin formulations?
Miacalcin
Calcimar
Cibacalcin (synthetic human calcitonin)
What do bisphosphonates bind strongly to?
Bone mineral
Hydroxyapatite
What is ONJ? Which drug is this associated with?
It is osteonecrosis of the jaw associated with bisphosphonates
What kind of relationship does PTH have with Ca++ levels?
Inverse relationship
What receptors recognize Ca++ in the body?
CaSR (Ca++ sensing receptor)
What is the MOA of PTH?
It increases the insertion of calcium channels
What are some symptoms related to hypoparathyroidism?
Death, convulsions, tetany, muscle spasms
What is the treatment for hypoparathyroidism?
Vitamin D with Ca++ supplementation
What is primary, secondary hyperparathyroidism? How do you treat both?
Primary is caused by hyperplasia or adenoma
Secondary is increased PTH bc of low Ca++ in plasma due to malabsorption or renal disease
Primary - surgery
Secondary - correct underlying cause
What cell secretes calcitonin? (specific site on thyroid)
On the C cells of the parathyroid
What can you use to treat Paget’s disease?
Calcitonin
What is Paget’s Disease?
Disease characterized by large amounts of PTH and calcitonin
