Parathyroid Flashcards

1
Q

What is the synthetic PTH hormone (rhPTH) drug on the market? Frequency of use?

A

Forteo

Chronic leads to bone break down
Intermittent therapy leads to bone formation

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2
Q

What are some preparations of calcitonin formulations?

A

Miacalcin
Calcimar
Cibacalcin (synthetic human calcitonin)

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3
Q

What do bisphosphonates bind strongly to?

A

Bone mineral

Hydroxyapatite

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4
Q

What is ONJ? Which drug is this associated with?

A

It is osteonecrosis of the jaw associated with bisphosphonates

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5
Q

What kind of relationship does PTH have with Ca++ levels?

A

Inverse relationship

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6
Q

What receptors recognize Ca++ in the body?

A

CaSR (Ca++ sensing receptor)

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7
Q

What is the MOA of PTH?

A

It increases the insertion of calcium channels

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8
Q

What are some symptoms related to hypoparathyroidism?

A

Death, convulsions, tetany, muscle spasms

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9
Q

What is the treatment for hypoparathyroidism?

A

Vitamin D with Ca++ supplementation

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10
Q

What is primary, secondary hyperparathyroidism? How do you treat both?

A

Primary is caused by hyperplasia or adenoma
Secondary is increased PTH bc of low Ca++ in plasma due to malabsorption or renal disease

Primary - surgery
Secondary - correct underlying cause

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11
Q

What cell secretes calcitonin? (specific site on thyroid)

A

On the C cells of the parathyroid

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12
Q

What can you use to treat Paget’s disease?

A

Calcitonin

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13
Q

What is Paget’s Disease?

A

Disease characterized by large amounts of PTH and calcitonin

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