Basic Random Facts Flashcards
Supraoptic nerve transports what hormone?
Oxytocin
Paraventricular nerve transports what hormone?
ADH
Hormones fall into what two general classes? Where are the receptors found for both?
Water soluble (receptors on surface of target cell) Lipid soluble (receptors on nucleus or sometimes cytoplasm)
Which disease is associated with low amounts of ADH? What two categories of deficiencies are there?
Diabetes insipidus
- nephrogenic
- neurogenic
What two drugs can be used as ADH replacements? Which one appears to have more advantages? What are they?
Pituitrin and Desmopressin
Desmopressin seems to be better because it has a long duration of action and it acts more on the V2 receptor leading to a better antidiuretic effect.
Why is the GH effect on the metabolism of carbohydrate and lipid complicated?
a) several hormones are involved in CHO metabolism. GH + insulin is an anabolic effect
b) GH switches fuel source to elevated blood levels of CHO (antagonizes insulin action) however it also supports CHO storage.
GH acts on which three main compartments in the body? IGF?
GH
- Adipose tissue
- Liver
- Muscle
IGF
- Muscle
- Chondrocytes
- Bone, Heart, Lungs
When GH binds to its receptor, what must happen first?
Receptors need to dimerize in order to activate tyrosine kinase
Which hormone is responsible for increasing levels of prolactin? Which hormone inhibits it? What increases the concentration of the inhibitor?
PRH
PRIH inhibits PRH and regulates it. More Dopamine increases PRIH
Ergots can be used for what?
Reducing hemorrhage and for abortion
GH is mainly responsible for?
Lipolysis and gluconeogenesis
What is IGF-1 responsible for?
Anabolic and growth-promoting effects
Synthetic GH are?
Somatrem
Somatropin (identical to natural GH)
