Paraneoplastic Syndrome

Question 1

Endocrine effects?

Answer 1

Hypercalcemia
Hypoglycemia
ACTH-like substance
Hyperestrogenism

Question 2

Cancer associate with hypercalcemia?

Answer 2

Dog: lymphoma, AGASACA, myeloma
Cat: SCC, lymphoma

Question 3

Mechanism of hypoglycemia

Answer 3

1-overproduction of insulin
2-insulin like growth factor
3-increased expression of insulin receptors
4- increased glucose utilization by cancer
5- decreased glycogenolysis
6- binding of M proteins to insulin

Question 4

Most common cancer that results in hyperestrogenism ?

Answer 4

Sertoli cell tumor

Question 5

Which Ig are over produce in multiple myeloma?

Answer 5

IgG and IGA

Question 6

Cutaneous paraneoplastic syndrome are ____

Answer 6

• Feline alopecia (pancreatic and biliary carcinoma)
• Superficial necrolytic dermatitis (glucagon secreting tumor)
• Nodular dermatofibrosis

Question 7

Which cancer can result in glomerulonephrititis?

Answer 7

Lymphocytic leukemia

Question 8

Which cancer is associated with hypertrophic osteopathy ?

Answer 8

Intra-thoracic masses

Via stimulation of afferent nerves that increased blood flow to the extremities