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Oncology > Kirks > Flashcards

Kirks Flashcards

1
Q

Nadir of neutropenia

1) most chemotherapeutic
2) carboplatin
3) lomustine

A

1) 5-10 days
2) 7-14 days (dogs) and 7-21 days (cats)
3) 7-28 days

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2
Q

Which chemotherapeutic can results in cardiac toxicity?

A

Doxorubicin

  • acute: arrhythmia (via increased histamine and catecholamines)
  • cumulative: decreased contractility
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3
Q

Which drug to give before doxorubicin to decrease toxicity?

A

Dexrazoxane

Both for cardiac or extravasation

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4
Q

Which chemo can results in urinary signs ?

A

Sterile hemorrhagic cystitis with Acrotelin

  • cyclophosphamide
  • ifosfamide
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5
Q

Which drug to decrease sterile hemorrhagic cystitis?

A

Furosemide with cyclophosphamide

Mesna with ifosfamide

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6
Q

Which chemotherapeutic is hepatotoxic?

A

Lomustine

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7
Q

Vésicant chemotherapeutic?

A

1) Vincrinstine/vinblastine/vinorelbine
Warm compress and DMSO

2) doxorubicin
Cold compress

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8
Q

Cat specificity with chemo drug ?

A
  • Doxorubicin = cumulative nephrotoxicity
  • Cisplatin = fatal pulmonary edema
  • 5-fluorouracil = fatal neurotoxicity
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9
Q

Ideal diet content for patient with cancer?

A 
High proteins + fat 
Low carbohydrate (provides energy to tumor)
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10
Q

Order of most common oral cancer in dogs ?

A

Melanoma, SCC, fibrosarcoma, peripheral odontogenic fibroma

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11
Q

Immunotherapy for oral neoplasia?

A

Xenogenic plasmid DNA vaccine

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12
Q

Chemotherapy for oral melanoma?

A

Carboplatin

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13
Q

Where are the apocrine glands of anal sac located ?

A

Within the stroma that lies between internal and external sphincter

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14
Q

Chemotherapy for perianal adenocarcinoma ?

A

Doxorubicin and platinum

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15
Q

Disease free interval for perianal adenocarcinoma of less than 5 cm with surgery?

A

2 years

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16
Q

AGASACA

Breed ?

A

Cocker

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17
Q

AGASACA : chemotherapy

A

Carboplatin
+/- mitoxantrone
Palladia

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18
Q

TCC metastasis sites?

A

LN, lung, liver, spleen

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19
Q

Pathogenesis of TCC:

1) Drugs
2) gender
3) breeds

A
  • Old flea control, herbicides, cyclophosphamide
  • obese females
  • Scottish-terrier, WHWT, shetland, beagle, wirehaired terrier
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20
Q

TCC treatment options ?

A

Piroxicam
Mitoxantrone
Intravesical mitomycin

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21
Q

Risks factors for mammary cancers?

A

Spay older
Medroxyprogesterone
Obesity at young age

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22
Q

Most common mammary gland involved in dogs ?

A

Caudal

23
Q

Negative prognostic factors

A

Ulceration, invasive, older, German Shepherd, large(>3 cm), male,

24
Q

Chemotherapy for cats with mammary carcinoma?

A

Doxorubicin, cyclophosphamide, mitoxantrone

25
Q

Diagnostic criteria for multiple myeloma?

A

Monoclonal gammopathy
Osteolytic bone lesion
>10-20% of plasma cell in bone marrow
Ig light-chains (Bence Jones) proteinuria

26
Q

Effects of paraproteins in multiple myeloma?

A

Neurological, retinopathy or cardiomyopathy

27
Q

Blood work changes with multiple myeloma ?

A

Azotemia, hypercalcemia, hyperglobulinemia, hypoalbuminemia, hypocholesterol

28
Q

Chemotherapy for multiple myeloma?

A

Melophalan :)

Chlorambucil, cyclophosphamide, lomustine

29
Q

Negative prognosticators in Multiple myeloma?

A

Hypercalcemia, bence jones, extensive lytic lésions

30
Q

Extramedullary plasma:

Breed

A

Cocker spaniels, terriers, boxer, golden retriever

31
Q

Extramedullary plasma:

Location

A

Skin (trunk, limbs and ears)
Mucosal membrane (oral and lips)
Rectum and colon

32
Q

OSA metastasis?

A

Lungs

33
Q

OSA: âge

A

Old

Peak at 2 years old

34
Q

Location of OSA

A

Metaphysis of long bones

  • distal radium
  • proximal humerus
  • proximal tibia
35
Q

OSA: breeds

A

Saint Bernard, Rottweiler, Great Dane , greyhound, Labrador

36
Q

HSA : over expression of which oncoprotein?

A

STAT3

37
Q

HSA: breeds

A

German Shepherd and golden

38
Q

HSA: most common primary sites

A

Spleen, right atrium, skin, SQ tissue , liver

39
Q

HSA metastasis

A

Lung liver omentum

40
Q

HSA : which changes in RBC ?

A

Schistocytes

41
Q

Which kinase is higher in dogs with HSA?

A

Thymidine

42
Q

HSA; chemotherapy

A

Doxorubicin

43
Q

Thyroid carcinoma:

Breeds

A

Boxers, beagle, golden and Siberian huskies

44
Q

What can medullary carcinoma produce ?

A

Calcitonin: results in hypercalcemia

45
Q

Thyroid carcinoma:

Metastasis

A

Lungs, retropharyngeal and SM I LN

46
Q

Prognosis for movable thyroid carcinoma with surgery?

A

2-3 years

47
Q

Which parasites can be associated with STS ?

A

Spirocerca Lupi

48
Q

Adjuvant metronomic therapy in STS?

A

Piroxicam and cyclophosphamide

49
Q

MST with pulmonary carcinoma with surgery and if < 5 cm?

A

10-13 months

50
Q

Pulmonary carcinoma chemotherapy?

A

Vindesine/cisplatin

Vinorelbine

51
Q

Cytology from thymoma?

A

Mature lymphocytes + mast cell

52
Q

Chemodectoma arises from which vessels?

A

Carotid or aortic body

53
Q

Chemodectoma: breed

A

Brachycephalic

Oncology (3 decks)

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