Kirks

Question 1

Nadir of neutropenia

1) most chemotherapeutic
2) carboplatin
3) lomustine

Answer 1

1) 5-10 days
2) 7-14 days (dogs) and 7-21 days (cats)
3) 7-28 days

Question 2

Which chemotherapeutic can results in cardiac toxicity?

Answer 2

Doxorubicin

• acute: arrhythmia (via increased histamine and catecholamines)
• cumulative: decreased contractility

Question 3

Which drug to give before doxorubicin to decrease toxicity?

Answer 3

Dexrazoxane

Both for cardiac or extravasation

Question 4

Which chemo can results in urinary signs ?

Answer 4

Sterile hemorrhagic cystitis with Acrotelin

• cyclophosphamide
• ifosfamide

Question 5

Which drug to decrease sterile hemorrhagic cystitis?

Answer 5

Furosemide with cyclophosphamide

Mesna with ifosfamide

Question 6

Which chemotherapeutic is hepatotoxic?

Answer 6

Lomustine

Question 7

Vésicant chemotherapeutic?

Answer 7

1) Vincrinstine/vinblastine/vinorelbine
Warm compress and DMSO

2) doxorubicin
Cold compress

Question 8

Cat specificity with chemo drug ?

Answer 8

• Doxorubicin = cumulative nephrotoxicity
• Cisplatin = fatal pulmonary edema
• 5-fluorouracil = fatal neurotoxicity

Question 9

Ideal diet content for patient with cancer?

Answer 9

High proteins + fat 
Low carbohydrate (provides energy to tumor)

Question 10

Order of most common oral cancer in dogs ?

Answer 10

Melanoma, SCC, fibrosarcoma, peripheral odontogenic fibroma

Question 11

Immunotherapy for oral neoplasia?

Answer 11

Xenogenic plasmid DNA vaccine

Question 12

Chemotherapy for oral melanoma?

Answer 12

Carboplatin

Question 13

Where are the apocrine glands of anal sac located ?

Answer 13

Within the stroma that lies between internal and external sphincter

Question 14

Chemotherapy for perianal adenocarcinoma ?

Answer 14

Doxorubicin and platinum

Question 15

Disease free interval for perianal adenocarcinoma of less than 5 cm with surgery?

Answer 15

2 years

Question 16

AGASACA

Breed ?

Answer 16

Cocker

Question 17

AGASACA : chemotherapy

Answer 17

Carboplatin
+/- mitoxantrone
Palladia

Question 18

TCC metastasis sites?

Answer 18

LN, lung, liver, spleen

Question 19

Pathogenesis of TCC:

1) Drugs
2) gender
3) breeds

Answer 19

• Old flea control, herbicides, cyclophosphamide
• obese females
• Scottish-terrier, WHWT, shetland, beagle, wirehaired terrier

Question 20

TCC treatment options ?

Answer 20

Piroxicam
Mitoxantrone
Intravesical mitomycin

Question 21

Risks factors for mammary cancers?

Answer 21

Spay older
Medroxyprogesterone
Obesity at young age

Question 22

Most common mammary gland involved in dogs ?

Answer 22

Caudal

Question 23

Negative prognostic factors

Answer 23

Ulceration, invasive, older, German Shepherd, large(>3 cm), male,

Question 24

Chemotherapy for cats with mammary carcinoma?

Answer 24

Doxorubicin, cyclophosphamide, mitoxantrone

Question 25

Diagnostic criteria for multiple myeloma?

Answer 25

Monoclonal gammopathy
Osteolytic bone lesion
>10-20% of plasma cell in bone marrow
Ig light-chains (Bence Jones) proteinuria

Question 26

Effects of paraproteins in multiple myeloma?

Answer 26

Neurological, retinopathy or cardiomyopathy

Question 27

Blood work changes with multiple myeloma ?

Answer 27

Azotemia, hypercalcemia, hyperglobulinemia, hypoalbuminemia, hypocholesterol

Question 28

Chemotherapy for multiple myeloma?

Answer 28

Melophalan :)

Chlorambucil, cyclophosphamide, lomustine

Question 29

Negative prognosticators in Multiple myeloma?

Answer 29

Hypercalcemia, bence jones, extensive lytic lésions

Question 30

Extramedullary plasma:

Breed

Answer 30

Cocker spaniels, terriers, boxer, golden retriever

Question 31

Extramedullary plasma:

Location

Answer 31

Skin (trunk, limbs and ears)
Mucosal membrane (oral and lips)
Rectum and colon

Question 32

OSA metastasis?

Answer 32

Lungs

Question 33

OSA: âge

Answer 33

Old

Peak at 2 years old

Question 34

Location of OSA

Answer 34

Metaphysis of long bones

• distal radium
• proximal humerus
• proximal tibia

Question 35

OSA: breeds

Answer 35

Saint Bernard, Rottweiler, Great Dane , greyhound, Labrador

Question 36

HSA : over expression of which oncoprotein?

Answer 36

STAT3

Question 37

HSA: breeds

Answer 37

German Shepherd and golden

Question 38

HSA: most common primary sites

Answer 38

Spleen, right atrium, skin, SQ tissue , liver

Question 39

HSA metastasis

Answer 39

Lung liver omentum

Question 40

HSA : which changes in RBC ?

Answer 40

Schistocytes

Question 41

Which kinase is higher in dogs with HSA?

Answer 41

Thymidine

Question 42

HSA; chemotherapy

Answer 42

Doxorubicin

Question 43

Thyroid carcinoma:

Breeds

Answer 43

Boxers, beagle, golden and Siberian huskies

Question 44

What can medullary carcinoma produce ?

Answer 44

Calcitonin: results in hypercalcemia

Question 45

Thyroid carcinoma:

Metastasis

Answer 45

Lungs, retropharyngeal and SM I LN

Question 46

Prognosis for movable thyroid carcinoma with surgery?

Answer 46

2-3 years

Question 47

Which parasites can be associated with STS ?

Answer 47

Spirocerca Lupi

Question 48

Adjuvant metronomic therapy in STS?

Answer 48

Piroxicam and cyclophosphamide

Question 49

MST with pulmonary carcinoma with surgery and if < 5 cm?

Answer 49

10-13 months

Question 50

Pulmonary carcinoma chemotherapy?

Answer 50

Vindesine/cisplatin

Vinorelbine

Question 51

Cytology from thymoma?

Answer 51

Mature lymphocytes + mast cell

Question 52

Chemodectoma arises from which vessels?

Answer 52

Carotid or aortic body

Question 53

Chemodectoma: breed

Answer 53

Brachycephalic