Paraneoplastic Disorders

Question 1

Subacute cerebellar degeneration (PCA-1 antibody) is associated with what?

Answer 1

• ovarian
• breast
• uterine carcinoma

This shows destruction of the purkinje cells, gloss, and mild chronic inflammatory infiltrate

Question 2

Limbic encephalitis with ANNA-1 ab in neuronal nuclei would be seen where?

Answer 2

Small cell carcinoma of lung

• Characterized by subacute dementia, perivascular inflammatory cuffs, microglial nodules, some neuronal loss, and gliosis

Question 3

Limbic encephalitis against NMDA receptor, hippocampal neurons

Answer 3

ovarian teratomas

• Characterized by subacute dementia, perivascular inflammatory cuffs, microglial nodules, some neuronal loss, and gliosis

Question 4

VGKC (voltage gated potassium channel)

Answer 4

Peripherlay neuropathies

Question 5

Eye movement disorders opsoclonus

Answer 5

neuroblastoma in kids

Question 6

Lambert eaten syndrome

Answer 6

Antibodies against voltage gated calcium channel

Question 7

Familiar tumor syndrome that causes a dysplastic gangliocytoma with mutation in PTEN IK3
->AKT

Answer 7

Cowden Syndrome

Question 8

What familial tumor syndrome has a TP53 mutation and causes medulloblastomas>

Answer 8

Li-Fraumeni Syndrome

Question 9

What syndrome causes medulloblastima or glioblastoma via mutation in APC or mismatch repair genes?

Answer 9

Turcot syndrome

Question 10

What syndrome causes medulloblastoma from mutations In PTCH resulting in up regulation of SHH?

Answer 10

Gorlin