PARAMYXOVIRUSES AND RUBELLA Flashcards
PROPERTIES OF PARAMYXOVIRIDAE
_________ is pleomorphic, with particles of 150 nm or more in diameter, occasionally ranging up to 700 nm
paramyxoviridae
PROPERTIES OF PARAMYXOVIRIDAE
______ protein underlies the viral envelope; it has an affinity to both the N and the viral surface glycoproteins and is important in virion assembly
Matrix protein (M PROTEIN)
CLASSIFICATION
_______ and ______ possess hemagglutinating and neuraminidase activities both carried by HN glycoprotein as well as the membrane fusion and hemolysin properties that both function of the F protein
respirovirus
rubulavirus
CLASSIFICATION
the ____ protein of RSV exhibits membrane fusion activity but no hemolysin activity
F protein
PARAMYXOVIRUS REPLICATION
A. Virus attachment, penetration, uncoating
Paramyxoviruses attach to host cells via the ________ (HN, H, G protein)
In the case of measles virus, the receptor is the membrane ______ or the ______ molecule
hemmaglutinin glycoprotein
CD46 or the CD150
PARAMYXOVIRUS REPLICATION
B. Transcription, Translation , and RNA Replication
Viral proteins are synthesized in the __________ and the quantity of each gene product corresponds to the level of mRNA transcripts
cytoplasm
PARAMYXOVIRUS REPLICATION
C. Maturation
____ protein is essential for particle formation, serving to link the viral envelope to the nucleocapsid
M protein
PARAMYXOVIRUS REPLICATION
C. Maturation
________ are believed to reflect sites of viral synthesis and have been found to contain recognizable nucleocapsids and viral proteins
inclusions
PARAINFLUENZA VIRUS INFECTIONS
_____ and ____ involve the larynx and upper trachea resulting in croup (laryngeotracheobronchitis)
bronchiolitis and pneumonia in ___________
types 1 and type 2
type 3
PARAINFLUENZA VIRUS INFECTIONS
The production of virus specific ________ antibodies during primary infections have been associated with disease severity
IgE
PARAINFLUENZA VIRUS INFECTIONS
the most common complication of parainfluenza virus infection is ___________
otitis media
PARAINFLUENZA VIRUS INFECTIONS
__________ is an avian paramyxovirus that produces pneumoencephalitis in young chickens and respiratory diseases in older birds
in humans it may produce inflammation of the _______
newcastle disease virus
conjunctiva
RESPIRATORY SYNCTIAL VIRUS INFECTIONS
RSV replication occurs initially in ______ in the __________
the epithelial cells of the nasopharynx
RESPIRATORY SYNCTIAL VIRUS INFECTIONS
___________ with high titer antibodies against RSV is of marginal benefit. Humanized antiviral monoclonal antibodies are available
immuneglobulin with high titer antibodies against RSV of marginal benefit
HUMAN METAPNEUMOVIR
