COMPLEMENT SYSTEM Flashcards
________________ is the lysis of cells such as bacteria, virus infected cells, and tumor cells
cytolysis
Cytolysis
process occurs through the development of the MAC
composed of
C5B, 6,7,8,9
_________ is the directed movement of leukocytes up a gradient concentration toward the site of infection
chemotaxis
_________ is the term used to describe how antibodies of C3b can enhance phagocytic engulfment of microbes
opsonization
___________ promote vasodilation and increase vascular permeability
two components are ____ and ____
anaphylatoxins
C3a C5a
PRODUCTS OF COMPLEMENT ACTIVATION
stimulates release of neutrophils from the bone marrow
C3
PRODUCTS OF COMPLEMENT ACTIVATION
Weak anaphylatoxin, spasmogen
C4a
PRODUCTS OF COMPLEMENT ACTIVATION
virus neutralization, opsonin, co-factor for convertases
C4b
PRODUCTS OF COMPLEMENT ACTIVATION
terminal component complex or MAC
C5a
REGULATION OF COMPLEMENT SYSTEM
important regulator of classical pathway
irreversibly binds to and inactivates C1r and C1s as well as MASP in lectin pathway
C1 inhibitor
REGULATION OF COMPLEMENT SYSTEM
regulates alternative pathway
reduce abmount of C5 convertase available
Factor H
REGULATION OF COMPLEMENT SYSTEM
protects C3b and stabilizes C3 convertase in alternative pathway
properdin
REGULATION OF COMPLEMENT SYSTEM
cleaves cell bound or fluid phase C3b and C4b which inactivates C3b and C4b
factor I
REGULATION OF COMPLEMENT SYSTEM
glycoprotein on surface of human cells
decal accelerating factor
REGULATION OF COMPLEMENT SYSTEM
inhibits action of C4b in classical pathway
C4b Binding Protein
