Paracetamol

Question 1

Other name for paracetamol

Answer 1

Acetaminophen

Question 2

what is paracetamol

Answer 2

analgesic

Question 3

mode of action

Answer 3

peripheral v central effect
limited inhibition of COX-1/2 activity
COX3 activity

Question 4

effects

Answer 4

no effects on platelet aggrations
little effect respiratory
little effect cardiovascular

Question 5

indications

Answer 5

first line dental
inflammatory conditions
where NSAIDs are CI

Question 6

Pharmokinetics

Answer 6

Tablet, capsule, elixir or suppository
IV preparation
well absorbed GI
peak plasma 60 mins
half life 2-4 hours

Question 7

contraindications

Answer 7

Absolute CIs - few

Question 8

Side effects

Answer 8

rare
skin reaction
blood dyscrasias

Question 9

standard adult dose

Answer 9

10-15mg.kg every 4-6 hours to a daily maximum of 4g

Question 10

Principle interactions

Answer 10

SCRAPPP
St Johns wort
carbemazepine
rifampicin
alcohol
phenobarbitol
phenytoin
primidone

Question 11

Lower back pain

Answer 11

no analgesic effect at all

Question 12

side effects

Answer 12

increased mortality
cardiovascular adverse effects
GI adverse effect
renal impairment

Question 13

acute liver damage dose

Answer 13

8g