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Therapeutics mod 6 > Aspirin/ NSAIDs > Flashcards

Aspirin/ NSAIDs Flashcards

1
Q

other name for aspirin

A

acetylsalicylic acid

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2
Q

therapeutic activity

A

Anti-pyrexic
anti-platelet
anti-inflammatory
analgesic

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3
Q

presentation

A

white tablet

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4
Q

route

A

dispersible
not dissolve in mouth

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5
Q

NSAID mechanism of action

A

COX isoenzyme inhibition
COX inhibitors reduces Eicosanoid synthesis

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6
Q

Actions of PGE2 and TXA in aspirin

A

regulate BP
renal effects
inflammatory response
duration and intensity of pain

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7
Q

aspirin effects on COX activity

A

COX-1> COX-2

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8
Q

aspirin indications

A

acute pain
dental pain
rheumatic fever
rheumatoid arthritis
other inflammatory disease

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9
Q

aspirin pharmokinetics

A

rapidly absorbed GI, stomach and SI
dose related efficiancy
half life 20-30 mins

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10
Q

aspirin contraindications and side effects

A

GI
Resp - AERD
Renal
CVS K+, HBP, oedema

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11
Q

aspirin contraindications

A

Reye’s syndrome
avoid in pregnancy
Overdose: 10-30g

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12
Q

aspirin interactions

A

4 ANTS like aspirin
Anticoagulants
Antihypertensives
Antidepressants
Anti-epilpetics
NSAIDs
Thrombocytes
Steroids

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13
Q

aspirin dose

A

300-900mg 4-6 hourly, maximum 4g daily

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14
Q

ibuprofen dose

A

400mg TDS max 2.4g /day

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15
Q

diclofenac dose

A

50mg TDS max 150mg/day

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16
Q

Aspirin therapeutic activity

A

weak organic acid
anti-inflammatory, analgesic, antipyretic, antithrombotic

Therapeutics mod 6 (6 decks)

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